N-containing compounds from Periplaneta americana and their activities against wound healing |
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| Authors: | Yong-Ming Yan Bin Xiang Hong-Jie Zhu Jing-Jing Qi Bo Hou Fu-Neng Geng |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. Guangdong Key Laboratory for Genome Stability &3. Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China;4. Sichuan Key Laboratory of Medical American Cockroach, Chengdu 610000, China |
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| Abstract: | ![]()
Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods. Biological activities of these isolates except 1, 9, 11, and 13 toward nitric oxide (NO) production, cell proliferation in HDFs, cell migration and angiogenesis in HUVECs were evaluated. |
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| Keywords: | Medicinal insect Periplaneta americana wound healing nitric oxide |
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