A new ionone derivative from the leaves of Picrasma quassioides |
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| Authors: | Chang Liu Rong-Rong Cheng Zhu-zhen Han Ying-bo Yang Yue Zhou Li Yang |
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| Affiliation: | The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents. |
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| Keywords: | Simaroubaceae Picrasma quassioides ionone derivatives anti-inflammatory |
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