Alkaloids from Melodinus henryi with anti-inflammatory activity |
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| Authors: | Jin-Qian Yu Xiao-Wei Sun Zhi-Wei Wang Lei Fang |
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| Affiliation: | 1. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China;2. School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250014, China;3. College of Biological Sciences and Technology, University of Jinan, Jinan 250022, China |
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| Abstract: | One new quinolinic scandine-type monoterpeniod alkaloid, 3-oxo-scandine (1), as well as seven known ones (2–8), was isolated from the roots of Melodinus henryi. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were prepared and evaluated for their anti-inflammatory activities by measuring the inhibitory activity of nitric oxide (NO) in vitro in RAW 264.7 mouse peritoneal macrophages. Compounds 6 and 7 showed significant activities with IC50 values of 8.54 and 5.19 μM, respectively. |
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| Keywords: | Melodinus henryi Apocynaceae monoterpeniod alkaloid isolation anti-inflammatory activity |
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