Nurses' perceptions of phase I clinical trials in pediatric oncology: a review of the literature.

A review of literature was conducted to explore nurses' perceptions of phase I clinical trials in pediatric oncology. Specifically, nurses' perceptions of the goals and outcomes, the nurse's role, and the informed consent process in pediatric oncology phase I clinical trials were investigated. Findings on possible factors influencing the nurses' perceptions and the quality of work-life of nurses working at pediatric phase I clinical trial centers were also searched. However, despite an extensive review of published works, no studies on nurses' perceptions of phase I trials in pediatric oncology were found. Therefore, this literature review consists of findings in similar or related studies such as nurses' perceptions of experimental therapies in the adult setting, adult patients' perceptions, parents' perceptions, or oncologists'perceptions of phase I clinical trials.