| 大输液中非代谢性杂质对小鼠的生化及病理影响 |
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| 引用本文： | 高飞絮,白希玲,王江东,李君霞.大输液中非代谢性杂质对小鼠的生化及病理影响[J].医药论坛杂志,2006,27(3):8-9. |
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| 作者姓名： | 高飞絮 白希玲 王江东 李君霞 |
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| 作者单位： | 河南省胸科医院中心实验室,郑州市,450003 |
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| 摘 要： | 目的观察静脉滴注中非代谢性小颗粒对血管的损伤。方法把试验小鼠随机分为4组,其中3组注入0.1ml不同微粒浓度的液体,然后饲养6个月后宰杀,观察血管内皮生长因子(VEGF)、肿瘤坏死因子(TNF)变化和病理性改良。结果实验动物的生化改变与正常小鼠有显著差别,病理观测发现有疾病性改变。结论试验小鼠的改变证明大量输液对机体有一定危害。
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| 关 键 词： | 血管内皮生长因子 肿瘤坏死因子 苏木素伊红 |
| 文章编号： | 1672-3422(2006)03-0008-02 |
| 收稿时间： | 12 17 2005 12:00AM |
| 修稿时间： | 2005年12月17 |
Biochemical and Pathological Influence of Nonmetabolism Particulates in Intravenous Transfusion on Mice |
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| GAO Feixu, BAI Xiling, WANG Jiangdong,et al.Biochemical and Pathological Influence of Nonmetabolism Particulates in Intravenous Transfusion on Mice[J].Journal of Medical Forum,2006,27(3):8-9. |
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| Authors: | GAO Feixu BAI Xiling WANG Jiangdong |
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| Institution: | Department of Central Laboratory of Henan Chest Hospital, Zhengzhou 450003, China |
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| Abstract: | Objective To study the pathological damage of particulate in intravenous transfusion to small vessel.Methods To divide the mice into 4 groups,3 groups mice were injected 0.1 ml liquid with different dense of particle,after thatmice being fed 6 months,mice were killed and taken serum to examine VEGF and TNF.Organs(kidneys,liver and lung)of mice were observed pathological change.Results There are lots of biochemical differences between the testing mice and normal group.There are also some pathological changes on the testing mice.Conclusion The change of testing mice tells us that a great quantity transfusion will bring some harm to our body. |
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| Keywords: | Vascular endothelial growth factor(VEGF) TNF HE |
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