艾滋病抗病毒治疗48例死亡患者相关因素分析

目的分析本院艾滋病抗病毒治疗死亡患者的相关因素。方法利用国家统一使用的DataFax抗病毒治疗信息系统所收集的数据资料,对抗病毒治疗死亡患者的相关情况进行分析。结果共有315例艾滋病患者接受治疗,有48例抗病毒治疗患者死亡。治疗前所有患者出现艾滋病临床Ⅲ期或Ⅳ期表现,CD4细胞最小值为4个/μl,最大值为263个/μl,平均为36.4个/μl。接受治疗时间最短1d,最长2年半,其中39例的治疗时间小于3个月。死于艾滋病相关性疾病42例,其中9例系统治疗无效死亡,11例治疗过程中出现机会性感染,放弃治疗在家中死亡;22例在停药后0.5～8月出现艾滋病相关疾病死亡。自杀4例,死亡原因不明2例。结论艾滋病抗病毒治疗患者的主要死亡原因是艾滋病相关疾病,依从性困难是患者死亡的另一个原因,经济困难、歧视和药物副作用与病人死亡有直接关系。

Related factor analysis of 48 dead patients with AIDS anti-viral treatment

Objective To analyze the related factors of the death in patients undergoing AIDS anti-viral treatment in our hospital.Methods The data were collected by the DataFax antiviral therapy information system which was used to analyze related conditions of dead patients with anti-viral treatment in our hospital.Results In the total of 315 AIDS patients accepted treatment from April of 2008 to June of 2010,in which 48 patients died.Of all the patients showed AIDS clinical Ⅲ stage or Ⅳ stage symptoms before treatment.Among them the CD4 cell minimum value was 4 cell/μl,the maximum value was 263 cell/μl with the average of 36.4 cell/μl.The minimum treatment time was 1 d,the maximum time was 2 years and a half,of which 38 patients were treated for less than 3 months.42 patients died due to AIDS-related diseases,including 9 patients who died of unsuccessful treatment.11 cases died of opportunistic infections and gave up treatment during the treatment at home.22 patients died of AIDS-related diseases in 0.5 month to 8 months after stopping the treatment.Four cases died by suicide,and two cases with an unknown cause of death.Conclusion The main cause of death in our patients undergoing AIDS anti-viral treatment was AIDS related disease,others include treatment discontinuation,economic hardship,discrimination and drug side effects.