2型糖尿病患者胃炎发生率及危险因素分析

目的通过病例对照研究分析2型糖尿病患者胃炎发生率及其危险因素。方法 450例2型糖尿病患者纳入研究。对照样本选用本院同时期非糖尿病患者并利用口服葡萄糖耐受实验排除糖尿病。病例与对照按性别、年龄及BMI匹配。结果胃炎在2型糖尿病患者中发生率为17.7%,对照中发生率为5.8%。单因素分析发现,胃炎危险因素包括年龄、性别、BMI、多次生产经历、家族胃炎患病史、高甘油三酯与胆固醇。多因素分析发现,年龄(RR=1.54,95%CI:1.1~2.1),女性(RR=1.6,95%CI:1.0~1.9),BMI(RR=1.5,95%CI:1.3~2.5)为胃炎发生的独立危险因素。结论 2型糖尿病患者胃炎发生率较高,年龄的增加,女性,高BMI为胃炎发生的独立危险因素。

Prevalence and Risk Factors of Gastritis Disease in Patients with Type 2 Diabetes

Objective To determine the prevalence and risk factors of gastritis in patients with type 2 diabetes.Methods Controls were selected from the general population and diabetes excluded by oral glucose tolerance test.Cases and controls were matched for age,gender,and body mass index (BMI).Results Gastritis was seen in 67 (17.7 ％) cases compared to 40 (5.8 ％) in controls (P＜0.01).In univariate analysis,risk factors for gastritis included age,femininity,BMI,multiparity,family history of gastritis,and high triglycerides and cholesterol with low high density lipoprotein cholesterol.In multivariate analysis,age,(relative risk [RR] 1.54,confidence interval [CI] 1.1 ～ 2.1),femininity (RR 1.6,CI 1.0 ～ 1.9),and BMI (RR 1.5,CI 1.3 ～ 2.5) were the independent risk factors for gastritis.Conclusion Patients with T2D are more vulnerable to gastritis than the general population.Old age,feminity and higher BMI are independently associated with gastritis.