肾移植术后痛风的预防和高尿酸血症的治疗

目的 探讨肾移植术后高尿酸血症和痛风的防治策略。方法 分析461例肾移植患者的临床资料。结果 发生血尿酸增高者42例，其中痛风2例，移植肾盂或输尿管结石3例，随访1～5年，4例患者血尿酸控制不理想，其余血尿酸均在正常水平。结论 高尿酸血症在肾移植术后较常见，主要与环孢素A的作用有关，肾移植术后痛风的发生率较低，其确切的原因目前尚不清楚。合理饮食、药物治疗可降低高尿酸血症及痛风的发生。

Preventation of Gout and Treatment of Hyperuricemia in Renal Transplant Recipients

Objective To investigate the rapeutic strategy of the hyperuricemia and gout after renal transplantation Methods The clinical data of 461 renal transplantation recipients were analyzed. Results 42 patients ofhyperuricemia after renal transplantation occurred, with 2 gout cases and 3 ureteral calculi or pyelolithiasis cases. 42 patients were followed up for ! to 5 years, blood uric acid level were effectively controlled except 4 patients. Conclusion Hyperuricemia is common in renal transplantation recipients, it is related to cyclosporine treatment, the reason why the low incidence of gout in renal transplant patient is not clear, reasonable diet and medication can be effective and safe.