| 大孔吸附树脂法分离精制逍遥丸 |
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| 引用本文： | 杨志欣 裴广杰,李永吉,王艳宏,王锐,刘俊.大孔吸附树脂法分离精制逍遥丸[J].中国中药杂志,2007,32(12):1164-1167. |
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| 作者姓名： | 杨志欣 裴广杰 李永吉 王艳宏 王锐 刘俊 |
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| 作者单位： | 黑龙江中医药大学,药学院,黑龙江,哈尔滨,150040 |
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| 摘 要： | 目的：通过对12种大孔吸附树脂筛选,寻找适用于分离精制逍遥丸的树脂种类及方法。方法：以芍药苷、柴胡皂苷A、阿魏酸、甘草酸的静态、动态吸附量和脱附率为指标大范围筛选树脂,通过单因素试验确定分离精制逍遥丸的优选操作条件。结果：D-101-1树脂具有较好的吸附性能和解吸效果。吸附完全后,先以水洗脱,除去杂质,再收集50%及70％乙醇洗脱液,药材与树脂(干重)的比例为5∶1。结论：D-101-1树脂综合性能良好,适用于逍遥丸的分离精制。
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| 关 键 词： | 逍遥丸 大孔吸附树脂 精制方法 |
| 文章编号： | 1001-5302（2007）12-1164-04 |
| 收稿时间： | 2005-12-10 |
| 修稿时间： | 2005-12-10 |
Separation and refine of Xiaoyao Pill by macroporous adsorption resin |
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| YANG Zhi-xin; PEI Guang-jie; LI Yong-ji; WANG Yan-hong; WANG Rui; LIU Jun.Separation and refine of Xiaoyao Pill by macroporous adsorption resin[J].China Journal of Chinese Materia Medica,2007,32(12):1164-1167. |
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| Authors: | YANG Zhi-xin; PEI Guang-jie; LI Yong-ji; WANG Yan-hong; WANG Rui; LIU Jun |
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| Institution: | College of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China |
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| Abstract: | Objective: To search for the method used in refining Xiaoyao Pill by macroporous adsorption resin, 12 types of macroporous adsorption resin were optimized. Method: Static and dynamic adsorption test and de-adsorption test were carried out to screen the best macroporous resin. The single factor test was applied to optimize the manipulation parameters of macroporous resin. Result: The macroporous resin D-101-1 possessed the strongest adsorption ability, in addition to an easy de-adsorption property. Conclusion: The D-101-1 type macroporous adsorption resin shows better comprehensive adsorption property. It is available for the refine Xiaoyao Pill. |
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| Keywords: | Xiaoyao Pill macroporous adsorption resin separation and refine |
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