双环醇片治疗甲亢性肝损害临床疗效分析

目的观察双环醇片治疗甲亢性肝损伤临床疗效。方法将97例甲亢性肝损伤患者随机分为两组,均常规选择抗甲状腺药物甲巯咪唑每日15mg口服,试验组49例,同时每日口服双环醇片75mg治疗,对照组48例,同时每日口服甘草酸二铵胶囊450mg,两组疗程均为4周。观察治疗前后的疗效。结果治疗4周后,两组肝功能均有不同程度改善,但试验组更为明显(P<0.05),在综合疗效方面,试验组显效率及总有效率均明显优于对照组,差异具有显著统计学意义(P<0.01)。经研究者判断,未发现药物相关不良事件。结论每日口服双环醇片75mg能有效治疗甲亢性肝损伤。

Clinical analysis on effect of bicyclol on liver injury induced by hyperthyroidism

Objective To observe the clinical effect of bicyclol on liver injury induced by hyperthyroidism.Methods Total of 97 patients with liver injury induced by hyperthyroidism were randomly divided into two groups:treatment group(49 cases) and control group(49 cases).Both groups received oral anti-thyroid drug tapazole(15 mg daily).Patients in treatment group were orally treated with bicyclol(75 mg daily),and in control group received diammonium glycyrrhizinate capsules(450 mg daily) orally.The treatment course for both groups was 4 weeks.Curative effect after the treatment was observed.Results After treatment for 4 weeks,liver function in both groups were improved,which were more significant in treatment group compared with the control group(P < 0.05).For the comprehensive effect,the rate of marked effect and total effect of treatment group were superior to that of the control group with statistical significance(P < 0.01).No drug-related adverse events detected during the treatment.Conclusions Bicyclol is effective and reliable in the treatment of liver injury induced by hyperthyroid.