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| P53及c—myc共同表达与输尿管癌生物学行为的关系 | |
| 引用本文： | 李光辉 陈向东. P53及c—myc共同表达与输尿管癌生物学行为的关系[J]. 中华泌尿外科杂志, 1997, 18(1): 33-35 |
| 作者姓名： | 李光辉 陈向东 |
| 作者单位： | 第二军医大学长海医院泌尿外科，镇江市第一人民医院泌尿外科，第二军医大学基础部病理解剖教研室 |
| 摘 要： | 为在分子水平上了解原发性输尿管癌发生、发展的机理，采用免疫组化法对１８例原发性输尿管癌和１４例输尿管息肉组织中Ｐ５３及ｃｍｙｃ表达及共同表达的意义进行了研究。结果：正常输尿管组织Ｐ５３及ｃｍｙｃ表达呈阴性；输尿管息肉分别为１４２９％及３５７１％；输尿管癌为５５５６％及８８８９％，共同表达阳性４４４４％。结论：Ｐ５３及ｃｍｙｃ基因在输尿管肿瘤的发生和发展过程中起着一定作用，共同表达阳性对于判定病理分级、分期，肿瘤复发及患者生存率以及输尿管息肉是否存在恶变潜在性等意义明显优于单一表达。 |
| 关 键 词： | 输尿管肿瘤 基因 |
Expression of P53 and c myc gene in primary ureteral carcinoma |
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| Li Guanghui,Cheng Xiangdong,Qian Songxi,et al.. Expression of P53 and c myc gene in primary ureteral carcinoma[J]. Chinese Journal of Urology, 1997, 18(1): 33-35 | |
| Authors: | Li Guanghui Cheng Xiangdong Qian Songxi et al. |
| Affiliation: | Li Guanghui,Cheng Xiangdong,Qian Songxi,et al.Department of Urology,Changhai Hospital,the Second Military Medical University,Shanghai 200433. |
| Abstract: | Expression of P53 and c myc gene have been studied with immunohistochemical technique in 18 cases of primary ureteral carcinoma and in 14 cases of ureteral polyp.The positive rate of P53 and c myc expression was 14.29% and 35.71% respectively in ureteral polyp while they were 55.56% and 88.89% in primary ureteral carcinoma with coexistence of the two in 44.44%.Both the P53 and c myc expressions were negative in normal ureteral tissues.P53 and c myc gene were believed to play a role in the pathogenesis and the development of primary ureteral carcinoma and the coexistence of the 2 was more helpful in the evaluation of tumor grade,clinical stage,liability of tumor recurrence,survival rate of the patients and the potentiality of malignant change in ureteral polyp. |
| Keywords: | Ureteral neoplasms Genes |
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