社区获得性肺炎病证结合疗效评价指标的筛选

目的:初步筛选社区获得性肺炎病证结合疗效评价指标。方法:采用前瞻性、多中心、大样本病例观察设计,收集全国4所三甲中医院肺炎患者辨证诊疗信息资料,采用Logistic回归分析、Spearman相关分析、重复测量方差分析方法分析中医辨证论治过程中各种指标的变化规律及其相互关系,并根据拟定的筛选标准进行疗效评价指标的初筛。结果:1 059例有效病例进入分析。发热、咳嗽等6个症状指标;体温、呼吸次数等5个体征指标;血常规指标、胸部影像等3个实验室指标;健康状况、生活乐趣等14个生存质量指标;自我照料的能力等10个疗效满意度指标;咳嗽、咯痰等13个患者报告的结局指标以及住院治疗时间等指标被初步筛选为疗效评价指标。结论:初步筛选出了相关社区获得性肺炎病证结合疗效评价指标,为进一步研究提供了重要依据。

Screening for the curative effect evaluation indexes of Community-Acquired Pneumonia based on studying of the mode of combination of disease and TCM syndrome

Objective: To preliminary screening for the curative effect evaluation indexes of community-acquired pneumonia based on studying of the mode of combination of disease and TCM syndrome.Methods: Adopted the observation designt of prospective,multicenter and large sample cases,collected the syndrome differentiation and treatment information of patients from 4 top Chinese medicine hospitals.Used SPSS 13.0 for windows statistical package,Logistic regression analysis,Spearman correlation analysis and repeated measures anova,we analysed the changes of various indicators and their relationship of the process of TCM syndrome differentiation and theatment,and screened the curative effect evaluation indexes according to the proposed screening criteria.Results: Through analysis of the information of 1 059 cases,6 symptoms indexs(fever,cough,and so on),5 individual disease indexs(the temperature,respiratory rate,et al),3 laboratory indexs(routine analysis of blood,imaging of the chest,and so on),14 indexs about quality of life(health status,joy of life,et al),10 curative effect satisfaction indexs(the ability of looking after themselves,and so on),13 patients report indexs(cough,stethocatharsis,and so on) and hospitalization time were preliminary screened as curative effect evaluation indexes.Conclusion: The curative effect evaluation indexes of syndromes under the mode of the disease binding study of patients with CAP were screened,which provided an important basis for further study.