三阴乳腺癌保乳治疗的疗效分析

目的 探讨三阴乳腺癌行保乳治疗后的疗效观察.方法 行保乳手术治疗的乳腺癌患者593例,所有病例的ER、PR、HER2/neu状态均经病理证实,根据ER、PR、HER2/neu的状态分为三阴乳腺癌(ER、PR、HER2/neu 均为阴性)及非三阴乳腺癌(ER、PR、HEE2/neu其中任何一项为阳性)两组.其中三阴乳腺癌92例,非三阴乳腺癌501例.结果 截止2009年11月,共随访593例,中位随访时间为52月,出现局部复发病例11例,远处转移28例,死亡16例.三阴乳腺癌组比非三阴乳腺癌组有较高的远处转移率,预后较差.但三阴乳腺癌和非三阴乳腺癌患者在术后的局部复发率上无明显差异.结论 三阴乳腺癌相较非三阴乳腺癌总体预后差,但没有证据说明三阴乳腺癌行保乳手术后局部复发率更高.患者不必因为三阴乳腺癌而缩小其保乳治疗的指征,三阴乳腺癌患者仍是保乳治疗的合适人选.

Efficacy of conservative surgery on triple negative breast cancer

Objective To compare the prognosis of triple negative and non-triple negative breast cancer after conservative surgery.Methods 593 patients with breast cancer were studied.All patients underwent conservative surgery therapy.All the patients′ ER,PR,HER2/neu were available.The patients were classified as triple negative if all three markers were negative and non-triple negative if not.Ninty-two cases were classified as triple negative and 501 as non-triple negative.Results Till Nov.2010,the median follow-up time of the 593 patients was 52 months.There was 11 in-breast relapses,28 distant relapses,and 16 deaths.The triple negative cohort had a poorer distant metastasis-free rate compared with the non-triple negative cohort.But there was no significant difference in local control between the triple negative and the non-triple negative.Conclusions Triple-negative breast cancer has a more aggressive clinical course than non-triple negative breast cancer.However,there is no evidence that these patients are at higher risk for local relapse after conservative surgery therapy.Triple-negative breast cancer is still the candidate for conservative surgery therapy.