首页 | 本学科首页   官方微博 | 高级检索  
     

藏药吉堪明目液毒理研究
引用本文:红梅,刘有菊,陈秋红. 藏药吉堪明目液毒理研究[J]. 亚太传统医药, 2012, 8(1): 20-23
作者姓名:红梅  刘有菊  陈秋红
作者单位:1. 青海省藏医药研究院药物研究所,青海西宁,810003
2. 青海高原医学科学研究所中心实验室,青海西宁,810012
基金项目:青海省重点科技攻关项目
摘    要:目的:通过藏药吉堪明目液的急性毒性、长期毒性与眼部刺激性实验,观察其毒性反应。方法:观察吉堪明目液对小鼠灌胃,测定最大耐受量的毒性反应;对家兔短期多次滴眼(15min/次,2h)与常规治疗7d滴眼(3次/d,7d)对兔眼的刺激情况;以1.1g/kg、0.56g/kg、0.28g/kg剂量组连续滴眼(4次/d)30天后,观察家兔每周体重、重要脏器系数、血象、血生化指标变化及眼球、重要脏器的病理检测。结果:吉堪明目液对小鼠最大耐受量(MTD)为生药39g.kg-1,无任何不良反应;短期多次给药眼刺激和常规治疗7天给药刺激性试验对兔眼角膜、虹膜、结膜综合评分为0,均无刺激作用,眼球病理检测无异常;连续滴眼30天后外观行为、每周体质量、血液学和血液生化学、脏器系数、与空白组比较无明显差异;眼球和脏器病理检测未发现与药物相关的明显病变,停药后也未见药物延迟毒性反应。结论:本藏药制剂未发现毒性反应,其临床应用是安全和无刺激的。

关 键 词:藏药  吉堪明目液  急性毒性实验  眼刺激实验  长期毒性实验

Toxicological study of Tibetan Medicine MMJK Eye Drops
Hong Mei,Liu Youju,Cheng Qiuhong. Toxicological study of Tibetan Medicine MMJK Eye Drops[J]. Asia-Pacific Traditional Medicine, 2012, 8(1): 20-23
Authors:Hong Mei  Liu Youju  Cheng Qiuhong
Affiliation:Hong Mei1,Liu Youju1,Cheng Qiuhong2(1.Qinghai Tibetan Medicine Institute,Xining,810003,china; 2.Qinghai Plateau Scientific Institute of Medcine,Xining 810012,China)
Abstract:Objective:To observe the toxicologicals study of tibetan medicine MMJK eye drops.Result:Mice were intragastrically administered with tibetan medicine MMJK eye drops,determine the maximum tolerated dose toxicity;observing the short-term multiple eye irritation(15min/time,2h)and treat the rabbit eyes 7 days(3time/d,7d);Rabbits in 3 experimental groups Received topical 1.1g/kg、0.56g/kg、0.28g/kg MMJK eye drops(4time/d),4tims daily for 30 days.The rabbits characters were observed,and their blood routines,blood biochemistry index,anatomic and pathologic changes of their major organs were also detected.Methods:Maximum tolerated dose(MTD)in mice of 39g/kg no any adverse reaction;the short-term multiple dose eye irritation and conventional treatment for 7 days irritation test on rabbit cornea,iris,conjunctiva,no significant irritation,detected no abnormal of eye pathology,the reactive scale and evaluating scale was zero;The outer appearance by comparing with control group,the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping adiministration later.Conclusion:The Tibetan preparation no found toxicity,its safety and no irritation in clinic application.
Keywords:Tibetan Medicine  MMJK Eye Drops  Acute Toxicity  the Eye Irritating Reaction  Long-term Toxic Test
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号