| 星点设计-效应面法优选保肝降脂浸膏水提工艺 |
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| 引用本文： | 谢华阁,谢辉,张兴德,李昕阳,顾娇.星点设计-效应面法优选保肝降脂浸膏水提工艺[J].中国药房,2014(35):3285-3288. |
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| 作者姓名： | 谢华阁 谢辉 张兴德 李昕阳 顾娇 |
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| 作者单位： | 南京中医药大学药学院,南京210023 |
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| 基金项目： | 江苏高校优势学科建设工程资助项目（No.ysxk2010） |
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| 摘 要： | 目的:优选保肝降脂浸膏水提工艺。方法:以加水量与提取时间为自变量,以多糖质量与浸出物得率为因变量,通过对自变量各水平多元线性回归及二项式拟合,采用星点设计-效应面法优选保肝降脂浸膏水提工艺。结果:优选的最佳工艺条件为加15倍量水提取3次,每次120 min。结论:优选的保肝降脂浸膏水提工艺简单可行,预测性良好。
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| 关 键 词： | 星点设计 黄精 海藻 多糖 |
Optimization of Water Extraction Technology for Lipid-lowering and Protective Liver Extract by Central Composite Design-response Surface Methodology |
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| XIE Hua-ge,XIE Hui,ZHANG Xing-de,LI Xin-yang,GU Jiao.Optimization of Water Extraction Technology for Lipid-lowering and Protective Liver Extract by Central Composite Design-response Surface Methodology[J].China Pharmacy,2014(35):3285-3288. |
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| Authors: | XIE Hua-ge XIE Hui ZHANG Xing-de LI Xin-yang GU Jiao |
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| Institution: | (College of Pharmacy,Nanjing University of TCM, Nanjing 210023, China) |
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| Abstract: | OBJECTIVE：To optimize water extraction technology of Lipid-lowering and protective liver extract. METHODS：The water extraction technology of Lipid-lowering and protective liver extract was optimized by central composite design-response surface methodology through multiple linear regression and binomial fitting of independent variable were conducted using amount of added water and extraction time as independent variables and the content of polysaccharide and the yield of extract as dependent variables. RESULTS：The optimal extraction technology was as follows： adding 15-folds water,extracting time of 120 min and extracting for 3 times. CONCLUSIONS：The optimal water extraction technology of Lipid-lowering and protective liver extract is simple,feasible and highly predictive. |
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| Keywords: | Central composite design Sealwort Seaweed Polysaccharide |
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