| 肿瘤耐药相关鞘糖脂CMH对人树突状细胞B7表达的影响 |
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| 引用本文： | 张健,张积仁,汪森明,赵燕,王兵. 肿瘤耐药相关鞘糖脂CMH对人树突状细胞B7表达的影响[J]. 解放军医学杂志, 2001, 26(3): 169-170,F003 |
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| 作者姓名： | 张健 张积仁 汪森明 赵燕 王兵 |
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| 作者单位： | 第一军医大学珠江医院;第一军医大学珠江医院;第一军医大学珠江医院;第一军医大学珠江医院;第一军医大学珠江医院 |
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| 基金项目： | 国家自然科学基金资助课题! (编号 3 9870 83 1),广东省自然基金资助课题!(编号 0 0 10 41) |
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| 摘 要： | 为了探讨肿瘤耐药相关鞘糖脂CMH在耐药肿瘤细胞免疫逃避中的作用,用柱层析的方法分离纯化了KBv200细胞的耐药相关中性鞘糖脂CMH,采用流式细胞仪技术检测CMH作用前后人树突状细胞（DC）B7抗原的表达。结果显示,CMH明显地抑制DC B7抗原的表达,说明肿瘤耐药相关鞘糖脂可能是通过对DC的影响而抑制机体的免疫反应。
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| 关 键 词： | 抗药性 多药 中性糖苷神经鞘脂类 树突细胞 |
INFLUENCE OF TUMOR MDR ASSOCIATED CMH ON THE EXPRESSION OF B7 IN DC |
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| Zhang Jian,Zhang Jiren,Wang Senming et al. INFLUENCE OF TUMOR MDR ASSOCIATED CMH ON THE EXPRESSION OF B7 IN DC[J]. Medical Journal of Chinese People's Liberation Army, 2001, 26(3): 169-170,F003 |
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| Authors: | Zhang Jian Zhang Jiren Wang Senming et al |
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| Affiliation: | Zhang Jian,Zhang Jiren,Wang Senming et al. Zhujiang Hospital,First Military Medical University,Guangzhou 510282 |
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| Abstract: | To investigate the role of tumor multidrug resistance (MDR) associated with CMH in the immunological evasion of MDR tumor cells, CMH was separated from neutral glycolipids of KBv 200by column chromatography, and the expression of B7 in DC was detected by flow cytometry. The results showed that the expression of B7 in DC was inhibited by CMH, it suggested the tumor MDR associated with glycolipids may inhibit human immune response by its effects on DC. |
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| Keywords: | drug resistance multiple neutral glycosphingolipids dendritic cells |
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