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| 健康老年男性雄激素受体基因CAG重复序列多态性研究 | |
| 引用本文： | 楚新梅,李小鹰,梁春红,叶玲,刘建伟. 健康老年男性雄激素受体基因CAG重复序列多态性研究[J]. 中华老年心脑血管病杂志, 2006, 8(12): 817-819 |
| 作者姓名： | 楚新梅 李小鹰 梁春红 叶玲 刘建伟 |
| 作者单位： | 解放军总医院,北京 100853 |
| 基金项目： | 全军十五面上课题(01AM301) |
| 摘 要： | 目的研究健康老年男性雄激素受体(AR)基因CAG重复序列多态性。方法使用DNA测序方法对102例健康老年男性AR基因外显子1 NH_2-端转录调节区内CAG重复序列长度进行测定。结果男性AR基因CAG重复数最短为8,最长为35。CAG重复数平均值为22．83±3．97。CAG重复数分布频率最多的为21(17．6%),22 (14．7%),23(15．7%)和24(6．9%),共占54．9%。结论健康老年男性AR基因CAG重复序列呈现多态性,多数集中在21-24。为进一步研究AR基因变异与疾病的关系提供依据。 |
| 关 键 词： | 受体,雄激素 外显子 DNA 多态性,限制性片段长度 |
| 文章编号： | 1009-0126(2006)12-0817-03 |
| 收稿时间： | 2006-05-11 |
| 修稿时间： | 2006-05-11 |
Study of AR gene CAG repeat polymorphism in old men |
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| CHU Xin-mei LI Xiao-ying LIANG Chun-hong. Study of AR gene CAG repeat polymorphism in old men[J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2006, 8(12): 817-819 | |
| Authors: | CHU Xin-mei LI Xiao-ying LIANG Chun-hong |
| Abstract: | Objective To analyze CAG length polymorphism of androgen receptor(AR)gene in old men. Methods A study was performed in 102 randomly selected male healthy subjects aged 62 - 92 years in Wan- shoulu district,Beijing.DNA sequencing of the CAG repeat in the N-terminal domain of the first exon of the AR gene was analyzed using Biosystems 3730xl DNA Analyzer.Results The AR allele length ranged from 8- 35 CAG repeat in 102 old men.The average value of CAG repeat was 22.83±3.97.The high frequencies of CAG repeat were 21(17.6%),22(14.7%),23(15.7%)and 24(6.9%),accounting for 54.9% in total. Conclusion Androgen receptor gene CAG length showed polymorphism in old men,most of the CAG length was focused on 21-24.This study offered the basic data on relationship between AR gene and disease. |
| Keywords: | receptors androgen exons DNA polymorphism restriction fragment length |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |