| 聚酯型儿茶素对小鼠的免疫调节作用 |
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| 引用本文： | 辛华雯,史霄燕,曾繁典.聚酯型儿茶素对小鼠的免疫调节作用[J].中国药房,2002,13(1):14-16. |
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| 作者姓名： | 辛华雯 史霄燕 曾繁典 |
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| 作者单位： | 1. 广州军区武汉总医院临床药理科,武汉市，430070
2. 同济医科大学临床药理研究所,武汉市，430030 |
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| 基金项目： | 湖北省“九五”重大科技攻关项目(981P1401) |
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| 摘 要： | 目的 :研究聚酯型儿茶素对正常小鼠及实验性免疫功能低下小鼠的影响。方法 :选用二硝基氟苯 (DNFB)致小鼠迟发型超敏反应 (DTH)模型、小鼠腹腔巨噬细胞 (PMΦ )吞噬鸡红细胞模型以及血清溶血素生成法 (HC50) ,分别观察对正常小鼠特异性细胞免疫、非特异性细胞免疫和体液免疫功能的影响。以环磷酰胺腹腔注射15mg/(kg·d)×4d造成免疫功能低下的模型 ,采用DTH、碳粒廓清法及血清溶血素生成法测定有关免疫指标。结果 :聚酯型儿茶素 (50、100、200mg/(kg·d)×7d)可明显增强正常小鼠的耳片肿胀度、腹腔巨噬细胞吞噬功能及血清溶血素生成 ,明显提高环磷酰胺所致免疫低下小鼠的DTH反应、碳粒廓清K和α值及HC50 值。结论 :聚酯型儿茶素对正常及免疫功能低下小鼠的细胞免疫和体液免疫均具有增强作用。
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| 关 键 词： | 聚酯型儿茶素 环磷酰胺 免疫调节 小鼠 |
| 文章编号： | 1001-0408(2002)01-0014-03 |
| 修稿时间： | 2001年11月9日 |
Immunomodulatory Effects of Theasinesin on Normal and Immunosuppressed Mice |
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| XIN Huawen.Immunomodulatory Effects of Theasinesin on Normal and Immunosuppressed Mice[J].China Pharmacy,2002,13(1):14-16. |
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| Authors: | XIN Huawen |
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| Abstract: | OBJECTIVE:The effects of theasinesin on the immune functions of normal and immunosuppressed nice were studied.METHODS:The immunosuppressed mice were induced by cyclophosphamide(15mg/(kg·d)×4d,ip).The immunom_odulatory effects of theasinesin were measured by delayed type hypersensitivity(DTH),phagocytosing function assay of peritoneal macrophage,cleaning charcoal particles method,and HC50 method.RESULTS:Theasinesin(50,100,200mg/(kg·d)×7d)could significantly intensify DTH caused by DNFB.It could also improve phagocytosing function of peritoneal macrophage and increase production of serum hemolysins in mice immunized with SRBC.The ear swelling,K,α and the level of serum hem_olysin that were lowered by cyclophosphamide were also markedly increased by theasinesin.CONCLUSION:Theasinesin has an enhanced effect on immunofuctions of normal mice ans immunosuppressed mice. |
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| Keywords: | theasinesin cyclophosphamide immunomodulatory effect mouse |
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