不同糖耐量良性前列腺增生患者的相关危险因素研究

目的：探讨不同糖耐量的良性前列腺增生(BPH)患者的危险因素。方法2013年12月至2015年6月选取99例年龄≥50岁的BPH患者，根据口服75 g葡萄糖耐量试验(OGTI)结果分为糖调节受损(IGR)组(n=53)和糖尿病(DM)组(n=46)，并选取20例糖耐量正常且无BPH患者为正常对照组。比较各组人群基线资料、生化指标、国际前列腺症状评分(IPSS)、前列腺体积(PV)。结果 DM组的体重指数(BMI)、空腹血糖(FPG)、糖负荷后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、2 h胰岛素(2 h Ins)、胰岛素抵抗指数(HOMA-IR)均高于IGR组、正常对照组(α'<0.017)；IGR组2 hPG、2 h INS均高于对照组(α'<0.017)；DM组甘油三酯(TG)高于IGR组(P<0.05)；从对照组到IGR到DM组，PV、IPSS呈逐渐增高趋势，且DM组、IGR组的PV、IPSS均高于对照组(α'<0.017)；多元线性回归分析显示PV与年龄(r=0.897，P<0.05)、BMI (r=1.488，P<0.05)呈正相关，IPSS与年龄呈正相关(r=0.427，P<0.05)。结论 BPH患者常合并血糖、血脂代谢紊乱，而年龄、BMI是前列腺增生的高危因素。

Associated risk factors in different state of glucose tolerance of patients with benign prostatic hyperplasia

Objective To explore the risk factors of benign prostatic hyperplasia (BPH) in patients with differ-ent glucose tolerance. Methods Ninety-nine patients with BPH, aged≥50 years old, were divided into impaired glu-cose regulation group (n=53, IGR group) and diabetes mellitus group (n=46, DM group) according to 75 g oral glucose tolerance test (OGTT) results. Twenty subjects of normal glucose tolerance without BPH were selected as control group. The baseline data, biochemical indexes, International Prostate Symptom Score (IPSS), prostate volume (PV) were ana-lyzed. Results The body mass index (BMI), fasting plasma glucose (FPG), 2 h plasma glucose (2 hPG), HbA1c, fast-ing insulin (FINS), 2 h insulin (2 h Ins), homeostasis model assessment of insulin resistance (HOMA-IR) were higher in DM group than IGR group and control group (α'<0.017). In IGR group, the 2 hPG, 2 h INS were significantly higher than those in control group (α'<0.017). The TG were higher in DM group than IGR group (P<0.05). From control group to IGR group, DM group, IPSS and PV showed a trend of increasing gradually, and PV, IPSS were higher in DM group and IGR group than control group (α'<0.017). Multiple linear regression analysis showed that PV was positively correlat-ed with age (r=0.897, P<0.05), BMI (r=1.488, P<0.05), and IPSS was positively correlated with age (r=0.427, P<0.05). Conclusion Blood glucose and lipid metabolic disorder is common in patients with BPH. Age and BMI were identified as significant risk factors for BPH.