| 直肠癌中p53基因与血管内皮生长因子表达的关系 |
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| 引用本文： | 熊静,熊永炎,李海波,吴云. 直肠癌中p53基因与血管内皮生长因子表达的关系[J]. 肿瘤防治研究, 2002, 29(4): 269-270 |
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| 作者姓名： | 熊静 熊永炎 李海波 吴云 |
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| 作者单位： | 1. 430071,武汉大学医学院
2. 武汉大学中南医院病理科 |
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| 摘 要： | 目的 研究直肠癌中血管内皮生长因子 (VEGF)的表达与 p5 3基因之间的关系。 方法 采用免疫组化方法对 4 5例直肠癌标本中VEGF和 p5 3基因的表达进行检测。 结果 在直肠癌中VEGF的表达率为 6 6 .6 7% (30 / 45 ) ,p5 3的表达率为 5 1.11% (2 3/ 45 ) ;在VEGF表达较高的区域 ,p5 3的表达亦较强 ,二者之间具有相关性 (P <0 .0 5 ) ,且与直肠癌的淋巴结转移相关 (P <0 .0 5 )。结论 在直肠癌中 ,VEGF的表达与 p5 3基因的表达呈正相关 ,在直肠癌的转移中起重要作用
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| 关 键 词： | 直肠癌 血管内皮生长因子 p53基因 |
| 文章编号： | 1000-8578(2002)04-0269-02 |
| 收稿时间： | 2001-10-08 |
| 修稿时间： | 2001-10-08 |
The relationship of the expression of p53 and vascular endothelial growth factor in rectal carcinoma |
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| XIONG Jing,XIONG Yong|yan,LI Hai|bo,et al The medical college of Wuhan university, wuhan,China. The relationship of the expression of p53 and vascular endothelial growth factor in rectal carcinoma[J]. Cancer Research on Prevention and Treatment, 2002, 29(4): 269-270 |
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| Authors: | XIONG Jing XIONG Yong|yan LI Hai|bo et al The medical college of Wuhan university wuhan China |
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| Affiliation: | XIONG Jing,XIONG Yong|yan,LI Hai|bo,et al The medical college of Wuhan university,430071 wuhan,China |
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| Abstract: | Objective To investigate the relationship of the expression of p53 and vascular endothelial growth factor (VEGF) in rectal carcinoma .Methods The expression of p53 and VEGF was detected by using immunohistochemical method in 45 Cases of rectal cancer tissue . Results The expression rate of VEGF and p53 was 66.67%(30/45),51.11%(23/45) respectively ; In the areas with higher VEGF expression there was more intensive p53 expression ,χ 2 test showed that VEGF expression was correlated with p53 ( P <0... |
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| Keywords: | Rectal carcinoma VEGF p53 Gene |
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