茱萸丸对大鼠实验性2型糖尿病的治疗作用

目的:观察茱萸丸对实验性2型糖尿病大鼠降糖、降脂等作用的影响。方法:Wistar大鼠110只,随机抽取50只作为正常大鼠实验组,其余60只为糖尿病大鼠组。糖尿病组以高脂饲料诱导加链脲佐菌素(STZ)30 mg.kg-1 ip建立2型糖尿病模型,7 d后选取成模大鼠50只。50只正常大鼠和50只糖尿病大鼠各自按随机数字表法分为正常组(0.9%生理盐水)、模型组(0.9%生理盐水)、药物组(盐酸二甲双胍0.2 g.kg-1)、茱萸丸组(低、中、高剂量组分别为0.75,1.5,3 g.kg-1),每组10只。连续ig给药2周后,观察各组大鼠体重、血糖、血脂的变化。结果:茱萸丸对实验性2型糖尿病大鼠血糖有明显降低作用(P<0.01),对正常大鼠血糖无明显变化;能明显改善糖尿病大鼠的血脂(P<0.01),明显降低大鼠TC,TG,对糖尿病大鼠治疗后期的体重减轻起到延缓的作用(P<0.01)。结论:茱萸丸能降低糖尿病大鼠的血糖,改善糖尿病大鼠的血脂和体重。

Therapeutical Effect of Zhuyu Wan on Type 2 Diabetes in Rats

Objective: To observe the hypoglycemic and hypolipemic effects of Zhuyu Wan on experimental type 2 diabetes in rats. Method: One hundred and ten Wistar rats were divided randomly into normal experimental group (50 rats),and diabetes experimental group (60 rats). The type 2 diabetic model was established through high fat diet and administration of Streptozotocin (30 mg ·kg^-1 ip). After 7 days,50 rats were selected from the diabetes group. The selected 50 diabetic rats were randomly divided intothe following groups:model group (ig normal saline),metformin group (ig metformin hydrochloride 0.2 g ·kg^-1),three Zhuyu Wan groups (ig 0.75,1.5,3 g ·kg^-1 accordingly). Another 50 normal rats were divided similarly as the above diabetic rats,except the model group was replaced by a normal control group. All the rats were treated accordingly for two weeks. Then,effectiveness was evaluated by determinations of body weight,blood glucose and blood lipid. Result: Zhuyu Wan showed an obvious effect on lowering the blood glucose level in type 2 diabetes rats (P<0.01),but it had no distinct effect on the blood glucose level for the normal rats. Zhuyu Wan could improve glucose obviously(P<0.01),decrease the index on TC and TG,and delay the weight loss in diabetic rats (P<0.01). Conclusion: Zhuyu Wan can lower blood glucose,and regulate blood lipid and weight loss in type 2 diabetic rats.