金铁锁化学成分、药理作用和临床应用研究进展

目的:总结金铁锁在化学成分、药理作用和临床应用方面的研究资料,发现研究缺口或不足,为金铁锁进一步开发提供参考。方法:查阅近些年有关金铁锁在化学成分、药理作用、临床应用等方面的文献、书籍,并对其进行汇总、分析、综述。结果:金铁锁的化学成分主要为三萜皂苷、环肽和内酰胺类等成分。药理研究表明,金铁锁具有镇痛、抗炎作用,并对免疫功能有一定的调节作用。从临床应用来看,金铁锁主要用于跌打损伤、风湿痹痛和出血性疾病。结论:金铁锁在抗炎、镇痛、止血等方面作用显著,但对该药其他作用研究较少,机制尚不很明确,建议加强金铁锁其他药效学评价及安全性研究,为民族药开发研究提供参考与依据。

Research Progress in Chemical Compoents, Pharmacological Effectiveness and Toxicity of Psammosilene tunicoides

Objective: To summarize the research progress on chemical components, pharmacological actions and toxicity of Psammosilene tunicoides , and provide useful references for the further research. Method: Recent journals and books for P. tunicoides were reviewed, and the progress of the chemical components, pharmacological actions and clinical utility was summarized. Result: Up to now, the chemical components isolated from P. tunicoides mainly include triterpenoid saponin, cyclopeptide, lactam, etc. Pharmacological references show that it can be used to relieve pain, anti-inflammation, and has certain effect on regulating the immune function. Clinical references show that it is mainly used to deal with fracture, rheumatic arthralgia, and hemorrhagic diseases. Conclusion: The pharmacological research mainly focuses on its anti-inflammation, pain-relieving and hemostasis effect, but seldom research in found for other effects, and the pharmacological mechanisms are not well known yet. We should carry out further studies on mechanism and toxicology, so that we can provide references and basis for the research and development of ethnodrugs.