| 芎芷痛瘀散消肿止痛作用的研究 |
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| 引用本文： | 葛争艳,郭宇洁,金龙,孟硕,任烨,刘建勋.芎芷痛瘀散消肿止痛作用的研究[J].中国实验方剂学杂志,2011,17(21):155-158. |
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| 作者姓名： | 葛争艳 郭宇洁 金龙 孟硕 任烨 刘建勋 |
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| 作者单位： | 中国中医科学院西苑医院实验研究中心,北京,100091 |
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| 基金项目： | 综合性中药新药研究开发技术大平台项目(2009ZX09301-005-1-8) |
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| 摘 要： | 目的:研究外用药芎芷痛瘀散的药理作用。方法:①大鼠分为模型组、阳性药组、芎芷痛瘀散3.2,1.6,0.8 g.kg-1组。后肢脱毛并抹药3 d,角叉菜胶致炎造模,测足跖体积变化。②大鼠背部脱毛,皮下注射空气及巴豆油造模。背部抹药1周,测量渗出液,肉芽肿称重。③小鼠双耳抹药,2次/d,巴豆油致炎造模,称耳重。④大鼠后肢脱毛,抹药3 d,甩尾法测痛阈。⑤小鼠腹部脱毛并抹药,2次/d,ip冰醋酸造模,扭体法测痛阈。⑥小鼠腹部脱毛并抹药3 d,iv高分子右旋糖苷造模,镜下观察肠系膜的血液流速及流态。结果:芎芷痛瘀散各剂量组可显著抑制大鼠足跖肿胀;大剂量组耳片肿胀率明显低于模型组;大剂量组小鼠扭体次数明显减少;中剂量组大鼠痛阈时间明显延长;大、中剂量组小鼠肠系膜微循环障碍明显改善。结论:芎芷痛瘀散能显著抑制大、小鼠的急性炎症,并提高其痛阈,改善小鼠肠系膜的血液流态,提示该药具有明显的消肿止痛和改善微循环障碍的作用。
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| 关 键 词： | 芎芷痛瘀散 动物模型 致炎剂 肿胀率 痛阈 微循环 |
| 收稿时间： | 2011/3/11 0:00:00 |
Study on Resolutive and Analgetic Effects by Xiongzhi Tongyu San Recipe |
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| GE Zheng-yan,GUO Yu-jie,JIN Long,MENG Shuo,REN Ye and LIU Jian-xun.Study on Resolutive and Analgetic Effects by Xiongzhi Tongyu San Recipe[J].China Journal of Experimental Traditional Medical Formulae,2011,17(21):155-158. |
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| Authors: | GE Zheng-yan GUO Yu-jie JIN Long MENG Shuo REN Ye and LIU Jian-xun |
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| Institution: | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091 |
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| Abstract: | |
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| Keywords: | Xiongzhi Tongyu San animal model inflammatory factors swollen rate threshold of pain micro circulation |
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