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| 高效液相色谱法测定白芍总苷的不确定度分析 | |
| 引用本文： | 饶毅,夏川川,周海滨,魏惠珍,刘玲,王跃生. 高效液相色谱法测定白芍总苷的不确定度分析[J]. 中国实验方剂学杂志, 2011, 17(19): 89-93 |
| 作者姓名： | 饶毅 夏川川 周海滨 魏惠珍 刘玲 王跃生 |
| 作者单位： | 1. 中药固体制剂制造技术国家工程研究中心,南昌,330006 2. 江西中医学院,南昌,330004 3. 宁波立华制药有限公司,浙江宁波,315174 |
| 摘 要： | 目的:建立高效液相色谱法同时测定白芍总苷中的芍药苷和芍药内酯苷的不确定度评定方法.方法:采用高效液相色谱法测定芍药苷和芍药内酯苷含量,分析影响其不确定度的因素来源,对各个不确定度因素进行评定,并计算合成不确定度,最终给出测量结果的扩展不确定度和置信水平.结果:不确定度评估芍药苷为±1.48％、芍药内酯苷为±0.66％.... |
| 关 键 词： | 高效液相色谱 白芍总苷 芍药苷 芍药内酯苷 测量不确定度 |
| 收稿时间： | 2011-03-10 |
Uncertainty Analysis for Total Glucosides of Paeony with High Performance Liquid Chromatography Method |
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| RAO Yi,XIA Chuan-chuan,ZHOU Hai-bin,WEI Hui-zhen,LIU Ling and WANG Yue-sheng. Uncertainty Analysis for Total Glucosides of Paeony with High Performance Liquid Chromatography Method[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(19): 89-93 | |
| Authors: | RAO Yi XIA Chuan-chuan ZHOU Hai-bin WEI Hui-zhen LIU Ling WANG Yue-sheng |
| Affiliation: | The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China;Jiangxi Traditional Medicine, Nanchang 330004, China;Ningbo Liwah Pharmaceutical Co.,Ltd, Ningbo 315174, China;The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China;Jiangxi Traditional Medicine, Nanchang 330004, China;The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China |
| Abstract: | Objective: To establish a high performance liquid chromatography method for uncertainty analysis of paeoniflorin and albiflorin of TGP. Method: HPLC method was established to determine the content of paeoniflorin and albiflorin. Each active component of uncertainty was calculated the variable parameters among the procedures. The combined uncertainty and extended uncertainty and confidence were finally obtained by synthesized the uncertainties of various component variables. Result: Uncertainty evaluation for paeoniflorin was ±1.48% and albiflorin is ±0.66%. Conclusion: The established mathematic model is reasonable and relible, it is applicable to the uncertainty analysis of high performance liquid chromatography method in the determination of drugs. |
| Keywords: | high performance liquid chromatography TGP paeoniflorin albiflorin measurement uncertainty |
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