过敏试验结合正交试验考察中药橡胶膏剂制备工艺

目的:优选中药橡胶膏剂制备工艺的最佳条件。方法:对中药橡胶膏剂制备工艺导致的安全性、舒适性等共性技术进行研究,对影响到安全性的溶媒进行了单因素考察;以剥离强度、柔软性、膏体均匀性为考察指标,采用正交试验法,对中药橡胶膏剂制备过程中影响膏体性质的3个因素(溶媒、打胶时间、空白基质各部分的添加顺序)进行研究,优选最佳条件。结果:制备工艺的最佳条件为正己烷为溶媒,用量50 mL,打胶时间2 h,橡胶匀浆先与软化剂混合,再加入增黏剂和填充剂。结论:优选后的橡胶膏剂过敏率低,舒适性好。

Preparation Technology of Traditional Chinese Medicine Adhesive Plaste by Allergy Test and Orthogonal Design

Objective: To optimize preparation process of traditional Chinese medicine adhesive plaste. Method: To investigate common technology of traditional Chinese medicine adhesive plaste in preparation process such as safty and comfortable,using single-factor test to investigate solvent which could cause allergy,employing peel strength,softness and paste uniformity as index,using orthogonal test to investigate factors which could influence paste properties as solvent, making gum time and the adding order of each bland matrix part,then optimized condition. Result: The best condition in preparation process was: n-hexane as solvent with 50 mL;2 h as making gum time; firstly,rubber homogenate mixed with softener,then adding viscous agent and filling agent. Conclusion: Optimized owning low allergy rate and high comfortable.