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| 连翘中连翘酯苷的大孔树脂纯化工艺 | |
| 引用本文： | 史秀峰,杨骏,黄孝春,玄振玉.连翘中连翘酯苷的大孔树脂纯化工艺[J].中国实验方剂学杂志,2011,17(15):14-18. |
| 作者姓名： | 史秀峰 杨骏 黄孝春 玄振玉 |
| 作者单位： | 1. 上海中医药大学附属龙华医院,上海,200032 2. 上海卢湾区香山中医医院,上海,200020 3. 上海玉森新药开发有限公司,上海,201203 |
| 基金项目： | 上海市优秀学科带头人计划(10XD1423100);国家重大新药创制科技重大专(2009ZX09313-008) |
| 摘 要： | 目的:优选连翘叶中连翘酯苷的最佳大孔树脂纯化工艺。方法:比较不同型号的大孔树脂和不同工艺条件对连翘酯苷的分离纯化能力。结果:确定AB-8树脂为连翘酯苷的纯化材料,其最佳工艺条件为药液质量浓度2.0 g.mL-1、吸附流速0.25 BV.h-1、洗脱流速3.0 BV.h-1。结论:工艺条件可以为连翘酯苷的制备提供理论依据。 |
| 关 键 词： | 连翘酯苷 大孔树脂 纯化工艺 |
| 收稿时间： | 2011/3/31 0:00:00 |
Purification of Forsythiaside from Leaf of Forsythia suspense by Macroporous Resins |
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| SHI Xiu-feng,YANG Jun,HUANG Xiao-chun and XUAN Zhen-yu.Purification of Forsythiaside from Leaf of Forsythia suspense by Macroporous Resins[J].China Journal of Experimental Traditional Medical Formulae,2011,17(15):14-18. | |
| Authors: | SHI Xiu-feng YANG Jun HUANG Xiao-chun and XUAN Zhen-yu |
| Institution: | SHI Xiu-feng1,YANG Jun2,HUANG Xiao-chun3,XUAN Zhen-yu3 (1.Shanghai Longhua's Hospital,Shanghai 200032,China,2.Shanghai Luwan District Xiangshan Chinese Medicine Hospital,Shanghai 200020,3.Shanghai Youseen Drug Development Corporation,Shanghai 201203,China) |
| Abstract: | Objective: To study the optimal methods of refining forsythiaside from leaf of Forsythia suspense Method: The ability of refining forsythiaside was compared in different types of macroporous resins and different technological conditions. Result: The AB-8 macroporous resin was the best for purifying forsythiaside in the following technological conditions: the sample concentration was 2.0 g ·mL-1, the flow rate was 0.25 BV ·h-1, and the eluting velocity was 3.0 BV ·h-1. Conclusion: The technological condition will provide bases for the preparation technique of traditional Chinese medicine containing forsythiaside. |
| Keywords: | forsythiaside macroporous resin purification |
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