黄萸巴布剂的解热、镇痛、抗炎作用

目的:观察黄萸巴布剂的解热、镇痛、抗炎作用。方法:分别采用干酵母、牛奶和伤寒、副伤寒甲、乙三联菌苗致热法观察黄萸巴布剂对3种致热原所致动物发热的影响;采用扭体法和热板法观察黄萸巴布剂的镇痛作用;采用蛋清致大鼠足跖肿胀法和醋酸致小鼠腹腔毛细血管通透性增高法观察黄萸巴布剂的抗炎作用。结果:黄萸巴布剂可显著抑制干酵母、牛奶、伤寒、副伤寒甲、乙三联菌苗所致发热反应;对醋酸和热板诱发的小鼠疼痛有明显的抑制作用;可减轻蛋清所致大鼠足跖肿胀度;降低醋酸引起的小鼠腹腔毛细血管通透性增高。结论:黄萸巴布剂具有明显的解热、镇痛和抗炎作用。

Antipyretic,Analgesic and Anti-inflammatory Effects of Huangyu Cataplasm

Objective: To study the antipyretic,antinociceptive and anti-inflammatory effects of Huangyu cataplasm (HYC). Method: The antipyretic effects of HYC were observed on febrile animals induced by three kinds of pyrogens including dry yeast,typhoid paratyphoik A,B vaccines,and milk,correspondingly. The analgesic effect was determined by writhing and hot plate tests in mice. Anti-inflammatory action was investigated on the model of paw edema caused by egg white and the pathological model with increasing vascular permeability induced by acetic acid in mice. Result: HYC had good antipyretic effects for experimental fever rabbits induced by dry yeast,typhoid paratyphoik A,B vaccines,and milk heating method. HYC could significantly inhibit the pain responses caused by hot plate and writhing responses induced by acetic acid. HYC could significantly decrease the degree of paw edema caused by egg white in mice and notably inhibit the degree of the increase in permeability of the capillaries. Conclusion: HYC shows considerable antipyretic,analgesic and anti-inflammatory effects