抗毒补心胶囊对阿霉素诱导大鼠慢性心肌损伤的保护作用

目的:研究抗毒补心胶囊对阿霉素诱导所致心肌损伤大鼠的心肌保护作用并探讨其机制。方法:SD大鼠60只,随机分成6组,除空白组外,均采用每周1次ip阿霉素3 mg.kg-1共6周,制备慢性心肌损伤模型,治疗组同时分别给予抗毒补心胶囊低、中、高剂量(0.4,0.8,1.6 g.kg-1),阳性对照组给予复方丹参片(0.45 g.kg-1)。检测心肌损伤大鼠左心射血分数(LVEF)、左室缩短分数(FS)及血浆脑钠素(BNP)、心肌谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量,并进行心肌病理检查。结果:经阿霉素诱导慢性心肌损伤后,大鼠血浆BNP水平升高,心肌组织MDA含量增高,GSH-Px,SOD活性降低(P<0.01);抗毒补心胶囊治疗组的LVEF和FS均较模型组高,血浆BNP水平下降,且心肌MDA含量降低,GSH-Px,SOD活性升高(P<0.05)。结论:抗毒补心胶囊具有抗氧化作用,对阿霉素所引起的慢性心肌损伤有保护作用。

Protective Effect of Kangdu Buxin Capsule on Chronic Myocardium Injury Induced by Adriamycin in Rats

Objective: To investigate the protective effect of Kangdu Buxin Capsule on chronic injury and cardiotoxicity induced by adriamycin (ADM) in rats. Method: Male SD rats were randomly divided into six groups. Besides the control group,each group were injected with adriamycin (ADM,3 mg·kg^-1 peritoneal injection) weekly for 6 weeks. Meanwhile,4 ADM-injected groups were received the treatment of Kangdu Buxin Capsule (0.4,0.8,1.6 g ·kg^-1) and Fufang Danshen tablet(0.45 g ·kg^-1),respectively. Survivors were observed for hemodynamics changes. LVEF,FS and B-type Natriretic peptide (BNP), the activities of GSH-Px and SOD,and MDA were measured and the hearts were removed for histological examination by light microscopy. Result: LVEF and FS were increased compared with the injury group,the activities of GSH-Px and SOD were higher,and the MDA lever was lower in therapy groups (P<0.05). Conclusion: Kangdu Buxin Capsule has protective effect and antioxidative effect on the cardiomyopathy of chronic heart disease induced by ADM in rats.