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A combined study using ligand-based design, synthesis, and pharmacological evaluation of analogues of the acetaminophen ortho-regioisomer with potent analgesic activity
Authors:Queiroz Luana M D  Rocha Josmar R  Leitão Andrei  Montanari Carlos A  da Silva Albérico B F  Sousa Pergentino J C  Borges Rosivaldo S
Affiliation:1. Programa de Pós‐Gradua??o em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Augusto Correa, SN, 66075‐110 Belém, PA, Brazil;2. Instituto de Química de S?o Carlos, Universidade de S?o Paulo, CP 780, 13560‐970 S?o Carlos‐SP, Brazil
Abstract:
Keywords:acetaminophen  analgesic effect  ligand‐based drug design  molecular modeling  opioid derivatives
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