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| Graves病易感基因研究进展 | |
| 引用本文： | 吴岚,韩刚,葛家璞. Graves病易感基因研究进展[J]. 国际内分泌代谢杂志, 2008, 28(Z1) |
| 作者姓名： | 吴岚 韩刚 葛家璞 |
| 作者单位： | 1. 新疆医科大学研究生院,乌鲁木齐,830054 2. 新疆维吾尔自治区人民医院内分泌科,乌鲁木齐,830001 |
| 摘 要： | Graves病(GD)是一种器官特异性自身免疫性疾病,目前一般认为是遗传和环境因素相互作用的结果.多年来在GD易感基因的研究上已经取得了很多进展,如人白细胞抗原(HLA)基因、细胞毒性T淋巴细胞抗原-4(CTLA-4)基因以及促甲状腺激素受体(TSHR)基因等.本文对免疫调节基因(如HLA基因、CTLA-4基因、CD40基因、白细胞介素基因、维生素D受体基因、抗原肽运载体基因、CBLB基因等)和甲状腺特异性基因(TSHR基因和甲状腺球蛋白基因)的研究现状进行综述. |
| 关 键 词： | Graves病 易感基因 |
Susceptibility genes of Graves' disease |
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| WU Lan,HAN Gang,GE Jia-pu. Susceptibility genes of Graves' disease[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(Z1) | |
| Authors: | WU Lan HAN Gang GE Jia-pu |
| Abstract: | Graves'disease(GD)is an organ-specific autoimmune disorder,which is commonly speculated as the result of interaction between heredity and environment.In the last years,significant progress has been made in understanding of the genetic contribution to the etiology of GD,including the human leukocyte antigen(HLA)gene,cytotoxic T lymphocyte antigen-4(CTLA-4)gene and thyroid-stimulating hormone receptor(TSHR)gene.This review focuses on immune-regulatory genes(HLA gene,CTLA-4 gene,CD40 gene,interleukin genes,vitamin D receptor gene,TAP2 gene,CBLB gene)and thyroid-specific genes(TSHR gene and thyroglobulin gene),as well as the recent advances of them. |
| Keywords: | Graves'disease Susceptibility gene |
| 本文献已被 万方数据 等数据库收录！ | |