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Pre- and perinatal complications and risk for bipolar disorder: a retrospective study |
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| Authors: | Dennis K. Kinney Deborah A. Yurgelun-Todd Mauricio Tohen Sharon Tramer |
| Affiliation: | a Laboratories for Psychiatric Research, NBG-28, McLean Hospital, 115 Mill Street, Belmont, Boston, MA 02178, USA b Brain Imaging Center, McLean Hospital, Belmont, Boston, MA 02178, USA c Bipolar and Psychotic Disorders Program, McLean Hospital, Belmont, Boston, MA 02178, USA d Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA e Lilly Research Laboratories, Indianapolis, IN, USA f Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA |
| Abstract: | Background: Many studies have reported that obstetric complications are risk factors for schizophrenia, but few studies have examined whether complications increase risk for bipolar disorder. Methods: Bipolar-disorder probands and their adult siblings were diagnosed using DSM-III-R criteria. Obstetrical data from maternal reports were scored, blind to diagnosis, applying published scales that take into account number and severity of complications. Results: Obstetric complication scores were significantly worse in probands than siblings without mood disorders. Limitations: Probands had relatively severe symptoms; research using more heterogeneous samples is needed. Conclusion: Results suggest obstetric complications are etiologically significant in bipolar disorder. |
| Keywords: | perinatal morbidity manic depressive psychosis prenatal disorder |
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