急性冠脉综合征患者冠状动脉重构与血脂水平的定量关系研究

目的探讨急性冠状动脉综合征（ACS）患者靶病变血管重构方式与血脂的关系。方法 106例接受冠脉介入治疗的ACS患者,靶病变血管行血管内超声（IVUS）检查,测量靶病变段及其近端参考段血管外弹力膜面积（EEM）,计算血管重构指数（RI）：靶病变段EEM面积与近端参考段EEM面积之比。根据RI分为正性重构组（RI〉1）69例和负性重构组（RI≤1）37例;根据年龄分为〉60岁组（55例）和〈60岁组（51例）。同期测定血清三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平。结果 RI与年龄显著负相关（r=-0.38,P=0.03）,与血清TG水平显著正相关（r=0.32,P=0.02）,血清TG水平正性重构组显著高于负性重构组（P=0.03）;年龄〈60岁组RI与血脂无相关关系,血脂水平正性重构亚组与负性重构亚组间无差异;年龄〉60岁组,RI与血清LDL-C水平显著正相关（r=0.53,P=0.03）,血清TG和HDL-C水平正性重构亚组显著高于负性重构亚组（P=0.01,P=0.04）。结论血脂水平影响ACS患者靶病变血管重构方式。

Quantitative Relationships between Coronary Vascular Remodeling and the Plasma Lipid Levels in Patients with Acute Coronary Syndrome

Objective To investigate the relationships between target lesion artery remodeling and the plasma lipid levels in patients with acute coronary syndrome(ACS).Methods Intravascular ultrasound(IVUS) analyses were performed in 106 ACS patients in the process of percutaneous coronary interventions.The remodeling index(RI) was calculated as the ratio between the external elastic membrane(EEM) at lesion site and the EEM at proximal reference.The patients were divided into the positive remodeling group(RI>1) and ne...