清热活血方治疗中晚期新月体性肾炎的临床研究

目的研究中西医结合治疗中晚期新月体性肾炎的疗效、方法采用随机、对照的方法对经肾穿刺确诊为中晚期新月体性肾炎的32例患者分为清热活血方组(16例)、西药对照组(16例)两组患者除l例外均用甲基泼尼松龙冲击治疗后改泼尼松口服治疗，部分患者加用环磷酰胺或吗替麦考酚酯，对血红蛋白低于90g／L者予皮下注射促红细胞生成素清热活血方组患者另以白花蛇舌草30g忍冬藤30g紫花地丁30g赤芍15g生地15g黄精15g党参30g丹参30g制大黄12g藿香12g等每日1剂水煎服一观察治疗3个月后患者的肾功能、贫血等改善情况及所需免疫抑制剂的数量、结果两组患者经治疗后肾功能均有改善，但以清热活血方组为好(P＜0．05)；经治疗后两组患者的贫血得到部分纠正，两组间差异无显著性；清热活血方组患者所用糖皮质激素较西药对照组明显为少(P＜0．01)结论中西医结合治疗新月体肾炎具有较好的疗效，且可减少糖皮质激素的用量

Clinical Study on Treatment of Mid-advanced Crescentic Nephritis by Qi ngre Huoxu e Recipe

ObjectiveTo evaluate the therapeutic effect of integrative Chinese a nd western medicine in treating mid-advanced crescentic nephritis (MACN). MethodsThirty-two patients, their diagnosis was confirmed as MACN by renal biopsy, w ere divided, adopting randomized, controlled method, into two groups, the treate d group and the control group, they were all, excepting one, treated with impact therapy of methyl-prednisolone followed with oral intake of prednisone, to par t of them cyclophosphamide or mycophenolate mofetil was given in addition, to tho se with hypo-hemoglobin (<90 g/L), subcutaneous injection of erythropoietin was administered. Decoction of Qingre Huoxue recipe (QHR), consisted of oldenlandia herb 30 g, honey-suckle stem 30 g, violet herb 30 g, red peony root 15 g, rehma n nia root 15 g, solomonseal rhizome 15 g, asiabell root 30 g, red sage root 30 g, prepared rhubarb 12 g and giant-hyssop herb 12 g, were additionally given one d ose per day to patients in the treated group. The renal function, improvement of anemia and immunosuppressive agents needed in patients were observed after 3 mo nths treatment. ResultsAfter treatment, renal function was improved in both gr oups, but the effect in the treated group was better than that in the control gr oup (P<0.05). Anemia was partially alleviated in the two group s with no signific ant difference. The dosage of glucocorticoids used in the treated group was obvi ously lesser than that used in the control group (P<0.01). ConclusionIntegrati ve Chinese and western medicine could treat crescentic nephritis to obtain good effect, and reduce the quantity of glucocorticoid necessity for treatment.