| VEGF-C、CXCR4在胰腺癌中的表达与意义 |
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| 引用本文： | 喻建,曹军.VEGF-C、CXCR4在胰腺癌中的表达与意义[J].医学新知杂志,2008,18(6). |
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| 作者姓名： | 喻建 曹军 |
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| 作者单位： | 1. 利川市人民医院外一科, 湖北利川,445400
2. 武汉大学中南医院普外科, 湖北武汉,430071 |
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| 摘 要： | 目的探讨VEGF-C、CXCR4在人胰腺癌转移和浸润过程中的作用与意义。方法47例胰腺癌病例,免疫组织化学S-P方法测定VEGF-C、CXCR4的表达;分析其表达与性别、年龄、肿瘤大小、转移、浸润程度之间的关系。结果VEGF-C、CXCR4在胰腺癌组织中的表达率分别为68.1%(32/47)和76.6%(36/47),主要位于细胞质和细胞膜。VEGF-C、CXCR4的表达强弱在不同性别患者间无区别(P>0.05),VEGF-C、CXCR4的表达强弱与患者年龄、肿瘤大小亦无明显关系(P<0.05)。在胰腺癌发生浸润的标本中VEGF-C、CXCR4表达强度明显增强(P<0.05),在胰腺癌发生转移标本中VEGF-C、CXCR4表达强度明显增强(P<0.01)。结论VEGF-C、CXCR4可能参与了胰腺癌的转移和浸润过程。
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| 关 键 词： | 胰腺癌 转移 浸润 |
Expressions and Clinical Significances of VEGF-C and CXCR4 in Human Pancreatic Cancer |
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| Yu Jian,Cao Jun.Expressions and Clinical Significances of VEGF-C and CXCR4 in Human Pancreatic Cancer[J].Journal of New Medicine,2008,18(6). |
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| Authors: | Yu Jian Cao Jun |
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| Institution: | Yu Jian~1 Cao Jun~2 1 The People's Hospital of Lichuan,Lichuan 445400 2 Department of General Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071 |
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| Abstract: | Objective To investigate the expressions and clinical significances of VEGF-C and CXCR4 in Human pancreatic Cancer.Method The expressions of VEGF-C and CXCR4 were detected in 47 human pancreatic cancer tissues by immunohistochemisty.The relationship between the expressions of VEGF-C and CXCR4 and clinical pathological parameter was figured out as well as that of their expressions.Result In human pancreatic cancer tissues,the positive rates of VEGF-C and CXCR4 were 68.1%(32/47)and 76.6%(36/47)respectively. Expressions of VEGF-C and CXCR4 were closely associated with tumor lymph node metastasis and histological classification,but were not associated with sex and age and diameter of tumor.Conclusion CXCR4 and VEGF-C possibly participate in the process of metastasis and invasion in human pancreatic cancer. |
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| Keywords: | VEGF-C CXCR4 |
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