| Effects of Iodium-Heterocyclic Compound on Physiological Properties of Guinea Pig Papillary Muscles |
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| 引用本文： | 曹维,赵德化,盛宝恒. Effects of Iodium-Heterocyclic Compound on Physiological Properties of Guinea Pig Papillary Muscles[J]. 中国人民解放军军医大学学报, 1987, 0(2) |
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| 作者姓名： | 曹维 赵德化 盛宝恒 |
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| 作者单位： | Department of Pharmacology Fourth Military Medical College，Xi'an，Department of Pharmacology，Fourth Military Medical College，Xi'an，Department of Pharmacology，Fourth Military Medical College，Xi'an |
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| 摘 要： | ![]()
Effects of iodium-heterocyclic compound(IHC-64)on physiologicalproperties of guinea pig papillary muscles were reported.IHC-64 not onlydepressed the myocardiac contraction with IC_(50)119.4±10.9μm,but also prolongedthe effective refractory period(ERP)from 190.5±13.9ms to 202.0±13.6 ms(P<0.01).Moreover,it increased the concentration for adrenaline to induceautomaticity of the papillary muscles by 2.8±1.1 folds(P<0.01)without markedeffects on its excitability.IHC-64 reduced significantly the contractility inducedby isoprenaline in potassium-depolarized guinea pig papillary muscles,makingthe isoprenaline dose-effect curves shift in a non-parallel manner.These resultsdemonstrate preliminarily that IHC-64 may be a new calcium antagonist.
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Effects of Iodium-Heterocyclic Compound on Physiological Properties of Guinea Pig Papillary Muscles |
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| Cao Wei Zhao Dehua Sheng Baoheng. Effects of Iodium-Heterocyclic Compound on Physiological Properties of Guinea Pig Papillary Muscles[J]. Journal of Medical Colleges of PLA(China), 1987, 0(2) |
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| Authors: | Cao Wei Zhao Dehua Sheng Baoheng |
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| Affiliation: | Cao Wei Zhao Dehua Sheng Baoheng Department of Pharmacology,Fourth Military Medical College,Xi'an |
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| Abstract: | ![]()
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| Keywords: | iodium-heterocyclic compound calcium antagonist contractility excitability automaticity ERP |
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