| 抗HIV-1基因治疗新进展 |
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| 引用本文： | 田雅茹,焦艳梅,张,彤,吴,昊.抗HIV-1基因治疗新进展[J].首都医学院学报,2014(1):101-107. |
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| 作者姓名： | 田雅茹 焦艳梅 张 彤 吴 昊 |
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| 作者单位： | 首都医科大学附属北京佑安医院感染中心,北京100069 |
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| 基金项目： | ＂十二五＂国家科技支撑计划重大项目（2012ZX10001-006）;北京市艾滋病研究重点实验室（BZ0089）. |
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| 摘 要： | 虽然高效抗反转录病毒治疗（highly active anti-retroviral therapy,HAART）取得了显著的成果,但是抗人类免疫缺陷病毒（human immunodeficiency virus,HIV）药物治疗仍有其局限性（如引起毒素蓄积和病毒突变）.基因治疗在理论上具有较好的抗HIV能力,可以通过持续干扰病毒复制,提供了阻止HIV进行性感染的希望.本篇综述主要探讨当前多种基因治疗策略及其最新进展.
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| 关 键 词： | 获得性免疫缺陷综合征 人类免疫缺陷病毒1型 基因疗法 慢病毒载体 |
Recent progress in the gene therapies against HIV-1 |
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| Tian Yaru,Jiao Yanmei,Zhang Tong,Wu Hao.Recent progress in the gene therapies against HIV-1[J].Journal of Capital University of Medical Sciences,2014(1):101-107. |
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| Authors: | Tian Yaru Jiao Yanmei Zhang Tong Wu Hao |
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| Institution: | ( Center oflnfectious Diseases, Beijing You＇an Hospital, Capital Medical University, Beijing 100069, China ) |
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| Abstract: | Highly active antiretroviral therapy （HAART） has achieved significant success, but anti-HIV drug treatment still has its limitation, such as causing drug toxicity and viral-escape mutants. Gene therapy has better ability of anti-HIV in theory. It offers the promise of preventing progressive HIV infection by sustained interference with viral replication. Gene-targeting strategies are being developed with RNA-based agents, such as ribozyme, antisense, RNA aptamers and small interfering RNA, and protein-based agents, such as the mutant HIV Rev protein M10, fusion inhibitors and zinc-finger nucleases. This review mainly discusses the various gene therapy strategies and recent progress. Many of these strategies are being tested in ongoing and planned clinical trials. |
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| Keywords: | acquired immune deficiency syndrome （AIDS） human immunodeficiency virus type I（HIV-1） gene therapy lentivector |
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