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复方枸杞合剂对实验性肝损伤保护作用的实验研究
引用本文:邢雁霞,李丽芬,邵鸿娥. 复方枸杞合剂对实验性肝损伤保护作用的实验研究[J]. 河北医学, 2006, 12(9): 887-889
作者姓名:邢雁霞  李丽芬  邵鸿娥
作者单位:大同大学医学院,山西,大同,037008;大同大学医学院,山西,大同,037008;大同大学医学院,山西,大同,037008
摘    要:目的:本文旨在探讨复方枸杞合剂对大鼠、小鼠实验性肝损伤的保护作用。方法:分别以四氯化碳(CCL4)造成大鼠和小鼠急性肝损伤模型,醋氨酚造成小鼠肝坏死模型;用赖氏法测定大鼠和小鼠血清SALT活力、甲醇法测定大鼠血清胆红素含量,并观察醋氨酚中毒对小鼠生存率的影响。结果:复方枸杞合剂能降低大鼠、小鼠SALT水平和胆红素含量,并显著提高醋氨酚中毒的小鼠生存率。结论:复方枸杞合剂对实验性肝损伤具有保护作用。

关 键 词:复方枸杞合剂  SALT  胆红素  肝损伤
文章编号:1006-6233(2006)09-0887-03

A Study of the Protective Effect of Compound Medlar Mixture on Experimental Hepatic Injury
XING Yan-xia,LI Li-fen,SHAO Hong-e. A Study of the Protective Effect of Compound Medlar Mixture on Experimental Hepatic Injury[J]. Hebei Medicine, 2006, 12(9): 887-889
Authors:XING Yan-xia  LI Li-fen  SHAO Hong-e
Affiliation:Medical College of Datong University , Shanxi Datong 037008, China
Abstract:Objective: To survery the protection of compound medlar mixture against experimental hepatic injury of mouse and rat.Method: Forming an acute hepatic injury model of mouse and rat by using carbon tetrachloride(ccl_4) and a hepatic necrosis model of mouse by using acetaminophen(AAP),measuring the activity of the serum alanine transaminase(SALT) of mice and rats by Reitman-Frankel's method,serum bilirubin content of rats by methanol method.The survival rate of mice responsing to AAP poisoning was also observed.Result: Compound medlar mixture can reduce SALT activity and bilirubin content of mice and rats,and can effectively increase the survival rate of mice responsing to AAP poisoning.Conclusion: Compound medlar mixture has an action to protect animal's hepatic cells from experimental injury.
Keywords:Compound medlar mixture  SALT  Bilirubin  Hepatic injury
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