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| 兰索拉唑关键中间体的合成工艺改进 | |
| 引用本文： | 赵海桥,王飞龙,范兴山,刘存领. 兰索拉唑关键中间体的合成工艺改进[J]. 齐鲁药事, 2011, 30(12): 687+691-687,691 |
| 作者姓名： | 赵海桥 王飞龙 范兴山 刘存领 |
| 作者单位： | 1. 山东方明药业集团股份有限公司,山东菏泽274500;山东大学药学院,山东济南250012 2. 山东方明药业集团股份有限公司,山东菏泽,274500 3. 山东方明药业集团股份有限公司,山东菏泽274500;沈阳药科大学药学院,辽宁沈阳110016 |
| 摘 要： | 目的改进兰索拉唑关键中间体的合成方法.方法通过改变文献合成过程中所用溶剂,单独用氢氧化钠的水溶液为溶剂,减少了环境污染,同时提高了产物的收率及操作的安全性.结果及结论新合成方法可使收率稳定在98%以上,高于文献报道的方法,降低了成本,更适合工业化的要求. |
| 关 键 词： | 兰索拉唑 关键中间体 工艺改进 |
Improvement on synthesis process of the key intermediate of lansoprazole |
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| ZHAO Hai-qiao,WANG Fei-long,FAN Xing-shan,LIU Cun-ling. Improvement on synthesis process of the key intermediate of lansoprazole[J]. qilu pharmaceutical affairs, 2011, 30(12): 687+691-687,691 | |
| Authors: | ZHAO Hai-qiao WANG Fei-long FAN Xing-shan LIU Cun-ling |
| Affiliation: | 1,3(1.Shandong Fangming Pharmaceutical Co.,Ltd.,Heze 274500,China;2.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;3.School of Pharmacy, Shenyang Pharmaceutical University,Shenyang 110016,China) |
| Abstract: | Objective To improve the synthetic method of the key intermediate of lansoprazole.Methods The solvent in synthesis process in literatures was changed.The aqueous solution of sodium hydroxide was used alone as solvent to reduce environmental pollution,while increasing the yield and safety of operation.Results and Conclusion This new synthesis method can steady the yield at 98%,which was higher than reported in the literatures,and was more suitable for industrial requirements. |
| Keywords: | Lansoprazole Key intermediate Process improvement |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |