血管内皮功能在良性前列腺增生症和冠心病之间的作用

目的 探讨良性前列腺增生症(BPH)和冠心病(CHD)两者之间的内在联系和发病机制。方法 测定56例BPH患者手术前后血浆血栓素(TxA2)、前列环素(PGI2)及其比值和一氧化氮(NO)、内皮素(ET)及其比值的动态变化，将其中伴有CHD和无CHD者分组比较。结果 BPH患者术后PGI2和NO明显下降，ET明显升高，TxA2／PGI2比值明显升高，NO／ET比值明显下降；与无CHD者相比，伴有CHD者术后不仅PGI2明显降低，且TxA2显著升高，手术后两者之间TxA2、PGI2水平及其比值和ET水平及其NO／ET比值变化均有显著差异。结论 BPH患者前列腺切除术后存在着直管内皮功能障碍，以伴有CHD的患者为甚，推测血管内皮功能失调可能是CHD和BPH两种疾病的内在联系和共同的发病机制之一。

Effection of endothelial function in their relationship between benign prostatic hyperplasia and coronary heart disease

Objective To investigate the relationship between benign prostatic hyperplasia(BPH) and coronary heart disease(CHD) and its mechanism in the elderly.Methods The dynamic variations of plasma Thromboxane A 2(TxA 2), Prostacyclin (PGI 2) and its ratio, nitric oxide (NO), endothelins (ET) and NO / ET in 56 patients with BPH before and after suprapubic prostatectomy were determined. At the same time, a comparison of two groups with and without CHD was carried out.Results The plasma PGI 2 and NO significantly decreased, the plasma ET obviously increased and the ratio of TxA 2 to PGI 2 increased significantly, the TxA 2/PGI 2 ratio much higher and the NO/ET ratio much lower after the operation in BPH patients,However,inpatients complicated with CHD,not only PGI 2 deceased but also TxA 2 increased remarkably compared with the group without CHD. The ET level and the ratio of NO to ET were different significantly between the two groups with and without CHD after operation.Conclusions There was a damaged endothelial function after prostatectomy in BPH patients, especially in BPH patients complicated with CHD. It suggest that endothelial dysfunction may be the inter-relationship and cogenerous mechanism between CHD and BPH.