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| 超声观察大鼠颈总动脉机械损伤模型 | |
| 引用本文： | 刘继东,崔连群,耿海华,张楠,朱梅,李锋,盖玉生. 超声观察大鼠颈总动脉机械损伤模型[J]. 解剖学杂志, 2006, 29(6): 770-773 |
| 作者姓名： | 刘继东 崔连群 耿海华 张楠 朱梅 李锋 盖玉生 |
| 作者单位： | 山东大学山东省立医院心内科,济南,250021;山东大学山东省立医院心脏超声科,济南,250021 |
| 摘 要： | 目的：用超声指标和病理指标评价大鼠颈总动脉机械损伤模型。方法：建立大鼠颈总动脉内皮剥脱模型,在术后1、7、28d分别超声观察颈总动脉管腔、血流速度、脉动指数(PI)和阻力指数(RI),与病理切片对照。结果：大鼠颈总动脉内皮剥脱后管腔狭窄,血流速度减慢,PI、RI增高,均于损伤第28天达峰值。结论：超声指标能够无创动态观察大鼠颈总动脉损伤及修复过程。 |
| 关 键 词： | 颈总动脉 创伤和损伤 超声技术 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-03-102006-07-21 |
Ultrasonic observation on mechanical injury model in rat carotid artery |
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| LIU Ji-Dong,CUI Lian-Qun,GENG Hai-Hua,ZHANG Nan,ZHU Mei,LI Feng,GAI Yu-Sheng. Ultrasonic observation on mechanical injury model in rat carotid artery[J]. Chinese Journal of Anatomy, 2006, 29(6): 770-773 | |
| Authors: | LIU Ji-Dong CUI Lian-Qun GENG Hai-Hua ZHANG Nan ZHU Mei LI Feng GAI Yu-Sheng |
| Affiliation: | Department of Cardiology, Shandong Provincal Hospital, Shandong University, Jinan 250021 ,China |
| Abstract: | Objective:To evaluate the de-endothelialization model in rat carotid artery with Doppler ultrasound and pathologic analysis.Methods.The rat model was established by denuding the carotid endothelium;dynamic chan- ges of inner diameters,hemodynamics,pulsatile index (PI) and resistance index (RI) were observed by ultrasonic technique at 1 d,7 d and 28 d after de-endothelialization and pathology findings were compared.Results:The lu- minal diameters,the maximal and minimal blood velocities were decreased after de-endothelialization,whereas the pulsatile index(PI) and resistance index (RI) were increased.Conclusion:Doppler ultrasonic technique can be used to observe the injury and reparation of rat carotid artery after de-endothelialization. |
| Keywords: | carotid artery trauma and injury ultrasonoic tecnique |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |