| 丙酰螺旋霉素I的分离与鉴别 |
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| 引用本文： | 秦德华,刘若莹. 丙酰螺旋霉素I的分离与鉴别[J]. 药学学报, 1996, 0(8) |
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| 作者姓名： | 秦德华 刘若莹 |
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| 作者单位： | 中国医学科学院(秦德华)，协和医科大学医药生物技术研究所(刘若莹) |
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| 摘 要： | 用大孔吸附树脂等方法分离丙酰螺旋霉素（ＰｒｏＳＰＭ），除得到以前分离的丙酰螺旋霉素ＩＩＩ（ＰｒｏＳＰＭＩＩ）外，又得到一个新成分。根据其理化性质和波谱［ＵＶ，ＨＲＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ（含ＤＥＰＴ）和１Ｈ１３ＣＣＯＳＹ］数据，并与ＰｒｏＳＰＭＩＩ比较，ＰｒｏＳＰＭＩＩ仅Ｃ３酰基不同，命名为丙酰螺旋霉素ＩＩ（ＰｒｏＳＰＭＩＩ）。
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| 关 键 词： | 丙酰螺旋霉素；大环内酯类抗生素；链霉素变株T100 |
ISOLATION AND IDENTIFICATION OF PROPIONYL SPIRAMYCIN II |
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| DH Qin and RY Liu. ISOLATION AND IDENTIFICATION OF PROPIONYL SPIRAMYCIN II[J]. Acta pharmaceutica Sinica, 1996, 0(8) |
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| Authors: | DH Qin and RY Liu |
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| Abstract: | Component A and B were isolated from propionyl spiramycin (Pro SPM) by means of column chromatography with macroreticular resin. Their physical and chemical properties were determined. On the basis of analytical data component A was shown to be identical with the previously reported Pro SPM III. The structure of component B was elucidated and designated as Pro SPM II. It is a new antibiotic. The only difference between A (Pro SPM III) and B (Pro SPM II) is the presence of a C 3 O Pro in A in contrast to the presence of a C 3 OAc in B. |
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| Keywords: | Propionyl spiramycin Marcolide antibiotics Streptomyces mycarofaciens var. T 100 |
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