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| BAG-1、VEGF在大肠癌中的表达及意义 | |
| 引用本文： | 王慧,陈龙,刘绍晨,梅立新,宫凤春,郑纪宁. BAG-1、VEGF在大肠癌中的表达及意义[J]. 承德医学院学报, 2009, 26(3): 243-246,F0002 |
| 作者姓名： | 王慧 陈龙 刘绍晨 梅立新 宫凤春 郑纪宁 |
| 作者单位： | 承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000 |
| 摘 要： | 日的:探讨抗凋亡基因BAG-1、血管内皮生长因子(VEGF)在大肠癌发生、发展中的作用及二者的相关性.方法:用免疫组织化学SABC法分别检测12例正常大肠粘膜、40例大肠癌组织BAG-1和VEGF蛋白的表达情况.结果:BAG-1和VEGF在大肠癌中的表达均明显高于正常粘膜(P<0.05,P<0.01).BAG-1在大肠癌中的表达与分化程度、淋巴结转移及DuKe's分期有关(P<0.01),与浸润深度无关(P>0.05);VEGF在大肠癌中的表达与分化程度、淋巴结转移、Duke's分期及浸润深度均有关(P<0.01).大肠癌中BAG-1的表达与VEGF有明显相关性(P<0.01).结论:BAG-1和VEGF参与了大肠癌的发生发展过程,可作为判断大肠癌生物学行为的参考指标. |
| 关 键 词： | BAG-1 VEGF 大肠癌 免疫组织化学染色 |
EXPRESSION AND SIGNIFICANCE OF BAG-1 AND VEGF IN COLONRECTAL CARCINOMA |
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| WANG Hui,CHEN Long,LIU Shao-chen,et al. EXPRESSION AND SIGNIFICANCE OF BAG-1 AND VEGF IN COLONRECTAL CARCINOMA[J]. Journal of Chengde Medical College, 2009, 26(3): 243-246,F0002 | |
| Authors: | WANG Hui CHEN Long LIU Shao-chen et al |
| Affiliation: | WANG Hui,CHEN Long,LIU Shao-chen,et al(Chengde Medical College,Hebei Chengde 067000,China) |
| Abstract: | Objective:To investigate the expressions of BAG-1 and VEGF in development of colorectal carcinoma and determine their relationships.Methods:SABC immunohistochemical staining was used to observe the expression of BAG-1 and VEGF protein in 12 normal colonrectal mucosa and 40 colonrectal carcinoma specimens.Results:The expression of BAG-1 and VEGF protein in colonrectal carcinoma were obviously higher than normal colonrectal mucosa(P<0.05,P<0.01) .In colorectal carcinoma,the BAG-1 expression was related to dif... |
| Keywords: | BAG-1 VEGF |
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