| 红色素基因RFLP及其与情感性精神病关系的研究 |
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| 引用本文： | 黄建民,张贵寅.红色素基因RFLP及其与情感性精神病关系的研究[J].汕头大学医学院学报,1996(2):12-13. |
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| 作者姓名： | 黄建民 张贵寅 |
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| 作者单位： | 汕头大学医学院生殖生物学研究室，哈尔滨医科大学遗传学教研室 |
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| 摘 要： | 以红色素基因全长ｃＤＮＡ作探针，２０例正常人，２６例双相型情感性精神病患者进行ＲＦＬＰ分析。ＳａｃＩ酶切显示：部分正常人和部分患者基因组ＤＮＡ产生的７．５ｋｂ，４．８ｋｂ，４．５ｋｂ呈多态性改变的片段。正常人具多态改变的占４５％，患者为４６．２％，按Ｘ染色体数计，正常人出现７．５ｋｂ限制性片段的频率为１４．３％，患者为３２．４％，但两者差异不显著。
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| 关 键 词： | 红色素基因 情感性精神病 连锁 RFLP |
Study on the Relationship Between Red Pigment Gene RFLP and Affective Disorder |
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| Huang Jianmin, Zhang Guiyin et al.Study on the Relationship Between Red Pigment Gene RFLP and Affective Disorder[J].Journal of Shantou University Medical College,1996(2):12-13. |
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| Authors: | Huang Jianmin Zhang Guiyin |
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| Abstract: | Using the cloned full length red pigment cDNA(HS7) as a probe, the authors analysed 20 normal individuals and 26 affective disorder(AD) patients and found polymorphisms in some AD patients and normal individuals. The polymorphic fragments of SacI were 7.5kb,4.8kb and 4.5kb respectively. 45% normal individuals and 46.2% AD patients showed polymorphisms. According to the numbers of the chromosome X, the frequency of the 7.5kb fragment in the normal individuals was 14. 3%, while 32. 4% in AD patients, but these two frequencies were not significantly different(x2=2. 13,df=1,P>0.05). |
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| Keywords: | Red pigment gene Restriction fragment length polymorphisms Affective disorder Linkage |
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