Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma |
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| Affiliation: | 1. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Department of Emergency Medicine, Baylor College of Medicine, Houston, TX;3. Department of Radiation Oncology, University of Miami, Miami, FL;4. Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX;5. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;6. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;2. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;3. Department of Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;1. Département de Psychologie, Université de Montréal, Canada;2. Research center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada;3. Montreal Neurological Institute, McGill University, Montréal, QC, Canada;4. Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, Canada;1. Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, 3801 University, Montreal, Quebec, Canada, H3A 2B4;2. Department of Psychology, McGill University, 1205 Doctor Penfield Avenue, Montreal, Quebec, Canada, H3A 1B1 |
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| Abstract: | ![]()
Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to ∼10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy. |
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