Interaction between hormone-dependent and hormone-independent human breast cancer cells |
| |
| Affiliation: | 1. China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, PR China;2. Key Laboratory of Tobacco Biological Effects, Zhengzhou 450001, PR China;3. Qingdao ETSONG Technology Co., Ltd, Qingdao 266000, PR China;1. Department of Civil and Environmental Engineering, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China;2. State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China;3. School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;4. Department of Environmental Science, Zhejiang University, Hangzhou 310058, China;5. School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;6. Environmental and Water Resources Engineering, Department of Civil and Environmental Engineering, Imperial College London, South Kensington, London SW7 2AZ, UK;7. Department of Earth and Atmospheric Sciences, University of Alberta, Edmonton, Alberta T6G 2E3, Canada;8. Faculty of Environmental Sciences, Czech University of Life Sciences, Kamýcká 129, 165 00 Prague-Suchdol, Czech Republic;9. Korea Biochar Research Center, O-Jeong Eco-Resilience Institute (OJERI), Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea |
| |
| Abstract: | ![]()
We developed two different models based on in vitro co-culture of hormone-dependent and hormone-independent cell lines to simulate the cell population heterogeneity of human breast cancer tumours. Oestrogen-dependent (MCF-7, ZR 75.1) and oestrogen-independent cell lines (MDAMB-231 BT-20) were grown under serum-free conditions. Co-culture of hormone-dependent and hormone-independent cell lines resulted in an increased cell yield compared to single cell cultures carried out at the same seeding ratios. Such an increase was not affected by addition of oestradiol and single growth factors (EGF, bFGF and IGF-I). These results allow us to conclude that in a heterogeneous cell population like human breast tumours, interaction between hormone-dependent and hormone-independent cell lines may result in a complex regulation of cell growth. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
