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| 甲状旁腺激素和甲状旁腺激素相关蛋白在正常及骨性关节炎软骨中作用机制的研究进展 | |
| 引用本文： | 付小霞,王文雅,张柳. 甲状旁腺激素和甲状旁腺激素相关蛋白在正常及骨性关节炎软骨中作用机制的研究进展[J]. 中国修复重建外科杂志, 2011, 0(3): 299-302 |
| 作者姓名： | 付小霞 王文雅 张柳 |
| 作者单位： | 华北煤炭医学院病理教研室;华北煤炭医学院附属医院骨外科; |
| 基金项目： | 河北省科技领军人才创新基金项目(06547008D-8)~~ |
| 摘 要： | 目的综述在正常和骨性关节炎(osteoarthritis,OA)的关节软骨及软骨下骨中,甲状旁腺激素(parathyroid hormone,PTH)和甲状旁腺激素相关蛋白(parathyroid hormone-related protein,PTHrP)的作用机制研究进展。方法广泛查阅近年来有关PTH和PTHrP对正常和OA关节软骨作用机制的文献,并进行总结与分析。结果 PTH和PTHrP可抑制OA软骨细胞的肥大分化及凋亡,促进其增殖,从而对OA软骨细胞起到保护作用;OA软骨下骨成骨细胞对PTH的反应下降。结论 PTH、PTHrP可能通过多种信号通路参与软骨降解和软骨下骨重塑,并对OA进展起到延缓和保护作用。 |
| 关 键 词： | 甲状旁腺激素 甲状旁腺激素相关蛋白 骨性关节炎 软骨 软骨下骨 |
PROGRESS OF PARATHYROID HORMONE AND PARATHYROID HORMONE-RELATED PROTEIN ON NORMAL AND OSTEOARTHRITIS CARTILAGES |
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| FU Xiaoxia,WANG Wenyal,ZHANG Liu. PROGRESS OF PARATHYROID HORMONE AND PARATHYROID HORMONE-RELATED PROTEIN ON NORMAL AND OSTEOARTHRITIS CARTILAGES[J]. Chinese journal of reparative and reconstructive surgery, 2011, 0(3): 299-302 | |
| Authors: | FU Xiaoxia WANG Wenyal ZHANG Liu |
| Affiliation: | FU Xiaoxia1,WANG Wenyal,ZHANG Liu2.1Department of Pathology,North Coal Medical College,Tangshan Hebei,063000,P.R.China,2Department of Orthopaedics,Aff iliated Hospital,North Coal Medical College. |
| Abstract: | Objective To review the progress of mechanism of parathyroid hormone(PTH) and parathyroid hormone-related protein(PTHrP) on normal and osteoarthritis(OA) cartilage and subchondral bones.Methods Recent 1iterature about the effects of PTH and PTHrP on normal and OA cartilage was reviewed.Results PTH and PTHrP can repress the hypertrophic differentiation and apoptosis of chondrocytes and promote their proliferation,which has a protection effect on chondrocytes of OA;osteoblasts from subchondral bone of OA show... |
| Keywords: | Parathyroid hormone Parathyroid hormone-related protein Osteoarthritis Cartilage Subchondral bone |
| 本文献已被 CNKI 等数据库收录！ | |