Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors |
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| Authors: | Nael Al Koudsi Ewa B. Hoffmann Abbas Assadzadeh Rachel F. Tyndale |
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| Affiliation: | (1) Department of Pharmacology and Toxicology, University of Toronto, 1 King’s College Circle, Medical Sciences Building, Rm 4326, Toronto, ON, M5S 1A8, Canada;(2) Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5S 2S1, Canada;(3) Department of Pharmacology and Toxicology and Psychiatry, University of Toronto, 1 King’s College Circle, Medical Sciences Building, Rm 4326, Toronto, ON, M5S 1A8, Canada; |
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| Abstract: | ![]()
Purpose We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. |
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