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| 心肌肥厚和扩张型心肌病中的Notch信号通路 | |
| 引用本文： | 甄一松,王晓建,惠汝太. 心肌肥厚和扩张型心肌病中的Notch信号通路[J]. 中国分子心脏病学杂志, 2010, 10(6) |
| 作者姓名： | 甄一松 王晓建 惠汝太 |
| 作者单位： | 中国医学科学院阜外医院心血管相关基因与临床教育部重点实验室,北京,100037 |
| 基金项目： | 北京协和医学院CMB基金,国家自然科学基金 |
| 摘 要： | Notch信号通路在脊椎动物和无脊椎动物中高度保守。它对正常心血管系统的发育有重要作用。心肌肥厚是许多疾病发展的一个重要阶段,但是它的形成机制到现在还没有完全清楚。扩张型心肌病是一组由于基因缺陷、心肌细胞损伤、心肌组织浸润使心脏肌肉层直接受累的疾病,其临床表现主要为心脏增大、心律失常,最终发生心力衰竭。最近的研究揭示Notch很可能在在这些疾病进程中起到非常关键的保护作用。 |
| 关 键 词： | Notch 信号通路 心肌肥厚 扩张型心肌病 |
Notch Pathway in Cardiac Hypertrophy and Dilated Cardiomyopathy |
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| ZHEN Yi-song,WANG Xiao-jian,HUI Ru-tai. Notch Pathway in Cardiac Hypertrophy and Dilated Cardiomyopathy[J]. Molecular Cardiology of China, 2010, 10(6) | |
| Authors: | ZHEN Yi-song WANG Xiao-jian HUI Ru-tai |
| Affiliation: | ZHEN Yi-song; WANG Xiao-jian; HUI Ru-tai.Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education; FuWai Hospital; Chinese Academy of Medical Sciences; Beijing 100037; China; |
| Abstract: | Notch signaling is a highly conserved pathway in vertebrates and invertebrates.It plays an important role in the development of the cardiovascular system.Cardiac hypertrophy is an important stage during the development of many diseases,but its mechanism has still not fully been understood.Dilated cardiomyopathy is a genetic defect due to myocardial cell damage,myocardial infiltration.Its clinical manifestations were cardiac enlargement,arrhythmias and heart failure in the long run.Recent studies reveal Notc... |
| Keywords: | Notch signaling Pathway Cardiac hypertrophy Dilated cardiomyoapthy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |