| 人精浆酸性磷酸酶对小鼠T淋巴细胞产生IL-2的影响 |
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| 引用本文： | 程丽萍 李伟毅. 人精浆酸性磷酸酶对小鼠T淋巴细胞产生IL-2的影响[J]. 生殖与避孕, 1997, 17(1): 19-22 |
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| 作者姓名： | 程丽萍 李伟毅 |
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| 作者单位： | 上海第二医科大学上海免疫研究所!上海，200025 |
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| 摘 要： | 本文研究了从正常人精浆中分离纯化的酸性磷酸酶（ACP）对BALB／c小鼠脾脏细胞来源的T淋巴细胞产生IL-2的影响。本文采用MTT生物学测定法测IL-2活性。实验证明：人糖浆ACP对小鼠T淋巴细胞产生IL-2有明显的抑制作用（P＜0．05），并且抑制作用随ACP剂量的增加而增强。这说明了精浆中大量ACP是构成精浆免疫抑制功能的重要组成成份之一。
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| 关 键 词： | 人精浆 酸性磷酸酶 T淋巴细胞 IL-2 |
The Effect of Acid Phosphatase from Human Semen on IL-2 Production by Mouse T Lymphocyte |
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| Cheng Li-ping, Li Wei-yi, Chen Guang-jie, Zhu Yun-feng. The Effect of Acid Phosphatase from Human Semen on IL-2 Production by Mouse T Lymphocyte[J]. Reproduction and Contraception, 1997, 17(1): 19-22 |
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| Authors: | Cheng Li-ping Li Wei-yi Chen Guang-jie Zhu Yun-feng |
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| Abstract: | The purpose of this study is to observe the effect of acid phosphatase (ACP) purified from human sernen on the IL-2 production by BALB/c mouse spleen T lymphocyte. MTT biological assay was used to measure the activity of IL-2. It has been proved that the production of IL - 2by mouse spleen T lymphocyte was significantly suppressed by human semen ACP (P<0.05)witb dose-dependent pattern. It has been suggested that a great amount of ACP existing in hu-man semen migbt be the main composition of immunosuppressive substance of human semen. |
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| Keywords: | Human semen ACP T lymphocyte IL-2 production |
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