磺胺吡啶、吡啶对培养的大鼠附睾上皮细胞的影响

柳氮磺胺吡啶（SASP）具抗生育作用。本文将合成SASP的原料磺胺吡啶及吡啶置培养的成年雄性SD大鼠的附睾各段上皮细胞中，共同孵育11天后，作培养细胞的形态学观察及上清液的生化测定。结果表明用药组与对照组的细胞在光镜下未见明显差异；磺胺吡啶组上清液内的唾液酸含量显著增高，在附睾尾部尤为明显（P＜0．01）；用药组与对照组的α－1，4糖苷酶的活性无显著差异。实验结果提示：磺胺吡啶对大鼠附睾上皮细胞的功能可有一定的影响。

Effects of Sulfapyridine and Pyridine on Cultured Epididymal Epithelial Cells from Rat

Sulphasalazine (SASP) possesses the effect of antifertility. Sulfapyridine(SP) and pyridine,the raw materials of SASP,were cocultured with epididymal epithelial cells from adult male SD rats, respectively. Eleven days later, the cultured cells were observed and the supernatants were assayed. The results showed that there was no significant difference in morphology between the experimental and control groups under LM. The static acid contents in the supernatants of SP groups were increased and were significantly different from those of the control groups,especially in the cauda (P<0. 01). There was no obvious difference between experimental and control groups in activities of α- 1,4 glucosidase. It is suggested that SP may affect the function of rat epidiymal epithelial cells.